PMID: 11326955May 1, 2001Paper

Detection of ET-1, TNF-alpha, oxidative radicals in sera of asthmatics and in sera and lung tissue of asthmatic guinea pigs

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
J DuY Guo

Abstract

To investigate the role of the ET-1, TNF-alpha and oxidative radicals of MDA and SOD in the pathogenesis of asthma and the effect of the nitric oxide synthase inhibitor, L-NAME to above factors. ET-1 was detected by the radio-immunoassay and TNF-alpha was detected by ELISA, SOD and MDA were detected by using thiobarbituric acid method. The contents of ET-1, TNF(and MDA in the serum of the asthmatic patients and in the serum and lung tissue of asthma models of guinea pigs were significantly increased, in the contrast, the content of SOD was decreased compared with those in the controls(P < 0.01). All the changes in the serum and in the lung tissues of the asthma models of guinea pigs returned to the levels of the controls by dexamethasone inhalation or L-NAME by intraperitoneal injection. ET-1, TNF alpha and the oxidative radicals and NO may play important roles in the pathogenesis of asthma, L-NAME, which is similar to the dexathamethsone, may either decrease the content of NO or decrease the content of ET-1, TNF alpha and oxidative radicals in asthma.

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