Detection of exogenous hydrocortisone in horse urine by gas chromatography-combustion-carbon isotope ratio mass spectrometry

Journal of Chromatography. B, Biomedical Sciences and Applications
R AguileraC K Hatton

Abstract

A gas chromatography-combustion-isotope ratio mass spectrometry method for confirmation of hydrocortisone abuse in horseracing and equine sports is proposed. Urinary hydrocortisone was converted to a bismethylenedioxy derivative which presents good gas chromatographic properties and brings an extra carbon contribution of only two carbon atoms. Synthetic hydrocortisone has a different 13C abundance from that of natural urinary horse hydrocortisone and the difference is significant, therefore exogenous and endogenous hydrocortisone can be distinguished.

References

Mar 1, 1990·Journal of Analytical Toxicology·S J ParkJ Park
Oct 3, 1994·Journal of Chromatography. B, Biomedical Applications·P VarelisL Lazarus

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Citations

May 28, 2005·Forensic Science International : Synergy·Sarah BensonClaude Roux
Jul 14, 2012·Drug Testing and Analysis·Adam T Cawley, Adrian V George
May 12, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Rodrigo AguileraFrancisco Aquino Neto
Jan 14, 2021·Drug Testing and Analysis·Fernando MoreiraMaria de Lourdes Bastos
Aug 14, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·J C MathurinJ de Ceaurriz
Mar 18, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·B Le BizecF André
Jun 23, 1999·Journal of Chromatography. a·W Meier-Augenstein

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