Detection of fetal fibronectin as a predictor of preterm delivery in high risk asymptomatic pregnancies

British Journal of Obstetrics and Gynaecology
S LeesonK J Baldwin

Abstract

The study was designed to determine whether fetal fibronectin would predict delivery before 37 weeks in women at high risk of preterm delivery. Forty-three women considered at risk of preterm delivery were recruited antenatally into a blind longitudinal study. Quantitative assays of fetal fibronectin were obtained from sequential high vaginal swabs taken fortnightly from 24 to 34 weeks of gestation. Fibronectin concentrations of 0.05 microgram/ml or more were considered as positive. Results were calculated by swab and by subject. The sensitivity of an individual fibronectin swab in predicting preterm delivery within 14 days of testing was 71% and the specificity was 93%. The overall positive predictive value was 31% and the negative predictive value was 99%. The sensitivity of the fibronectin swab in predicting delivery before 37 weeks was 17% and the specificity was 93%. The positive predictive value was 50% and the negative predictive value was 73%. For a woman who has had a positive swab the sensitivity in predicting preterm delivery within 14 days of testing was 80% and the specificity was 83%; a woman was counted as positive only if the final swab was positive and preceded delivery by not more than 14 days. The positive pr...Continue Reading

References

Feb 1, 1992·American Journal of Obstetrics and Gynecology·V C BallegeerA M Criel
Feb 1, 1992·American Journal of Obstetrics and Gynecology·D B BrubakerD Marinoff
Mar 5, 1992·The New England Journal of Medicine·Y Sadovsky, S A Friedman
Sep 5, 1991·The New England Journal of Medicine·C J LockwoodT J Garite
Aug 1, 1989·American Journal of Obstetrics and Gynecology·V BallegeerD Collen
Oct 1, 1993·American Journal of Obstetrics and Gynecology·C J LockwoodR L Berkowitz
Jan 1, 1994·American Journal of Obstetrics and Gynecology·M P NageotteA E Senyei
Feb 1, 1993·American Journal of Obstetrics and Gynecology·J C MorrisonR W Martin
Apr 1, 1993·American Journal of Obstetrics and Gynecology·R K Creasy

❮ Previous
Next ❯

Citations

Sep 1, 1985·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·V Brotanek, C Sureau
Sep 1, 1985·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A Guzman SanchezJ G Panduro Baron
Jul 2, 1998·Obstetrics and Gynecology·G FaronW D Fraser
Jul 4, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J L VoluménieD Luton
Feb 23, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dale OjutikuSusan Bewley
Jan 11, 2000·Clinical Obstetrics and Gynecology·H F Andersen
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·G J DaskalakisA J Antsaklis
May 2, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D A Dempsey, N L Benowitz
Jan 13, 2004·Clinics in Perinatology·Patrick S Ramsey, William W Andrews
Jan 31, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·C R PiresL C S Bussamra
Jun 20, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gilles FaronLeonardo Gucciardo
Feb 3, 2005·Obstetrics and Gynecology·Ashley S RomanAndrei Rebarber
Feb 17, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Andrew ShennanLucilla Poston
May 13, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·K E DuhigA H Shennan
Apr 1, 1997·British Journal of Obstetrics and Gynaecology·P F ChienP Owen
Dec 20, 2012·Glycoconjugate Journal·Magdalena Orczyk-PawiłowiczIwona Kątnik-Prastowska
Jul 31, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Manju ChandiramaniAndrew Shennan
Apr 7, 2016·Journal of Perinatal Medicine·Michela CentraGian Carlo Di Renzo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.