Detection of folic acid protein in human serum using reduced graphene oxide electrodes modified by folic-acid

Biosensors & Bioelectronics
Lijie HeSabine Szunerits

Abstract

The detection of disease markers is considered an important step for early diagnosis of cancer. We design in this work a novel electrochemical sensing platform for the sensitive and selective detection of folic acid protein (FP). The platform is fabricated by electrophoretic deposition (EPD) of reduced graphene oxide (rGO) onto a gold electrode and post-functionalization of rGO with folic acid. Upon FP binding, a significant current decrease can be measured using differential pulse voltammetry (DPV). Using this scheme, a detection limit of 1pM is achieved. Importantly, the method also allows the detection of FP in serum being thus an appealing approach for the sensitive detection of biomarkers in clinical samples.

References

Jul 29, 2011·Chemical Society Reviews·Maëlle PerfézouArben Merkoçi
Oct 1, 2011·Nanoscale·Ouarda FellahiRabah Boukherroub
Nov 2, 2011·Chemical Communications : Chem Comm·Izabela KaminskaRabah Boukherroub
Nov 15, 2012·The Analyst·John J CastilloJaime Castillo-León
Feb 1, 2013·The Analyst·Thandavarayan MaiyalaganSeeram Ramakrishna
May 16, 2015·Chemical Communications : Chem Comm·Randa AhmadClaire Mangeney
Sep 18, 2015·Chemical Society Reviews·Rajeshwer Vanjari, Krishna Nand Singh

❮ Previous
Next ❯

Citations

Jun 16, 2016·Advanced Drug Delivery Reviews·Jieon LeeDal-Hee Min
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Hadi BeitollahiMasoud Torkzadeh-Mahani
Jan 18, 2020·Micromachines·Yunlong BaiXueji Zhang
Oct 3, 2019·Micromachines·Mohsen MohammadniaeiMin-Ho Lee
Apr 27, 2018·Interface Focus·Sabine Szunerits, Rabah Boukherroub
Feb 27, 2020·Current Pharmaceutical Biotechnology·Li-Hua WangYong-Li Wang
Nov 17, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Jin Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Biosensors for Cancer Detection

Biosensors are devices that are designed to detect a specific biological analyte by essentially converting a biological entity (ie, protein, DNA, RNA) into an electrical signal that can be detected and analyzed. The use of biosensors in cancer detection and monitoring holds vast potential. Biosensors can be designed to detect emerging cancer biomarkers and to determine drug effectiveness at various target sites. Biosensor technology has the potential to provide fast and accurate detection, reliable imaging of cancer cells, and monitoring of angiogenesis and cancer metastasis, and the ability to determine the effectiveness of anticancer chemotherapy agents.