Detection of Fusobacterium nucleatum in culture-negative brain abscess by broad-spectrum bacterial 16S rRNA Gene PCR

IDCases
Catherine ChakvetadzeSylvain Diamantis

Abstract

Fusobacterium nucleatum is a strict anaerobic microorganism commensal to the human oropharynx and gastrointestinal tract, which causes a wide spectrum of human diseases and it is an important pathogen in abscesses. We report the case of a previously healthy 64-year-old woman with multiple abscesses due to Fusobacterium nucleatum, involving liver, pleura and brain. Fusobacterium was not recovered from blood cultures nor from culture of hepatic, pleural and brain drain fluid. The diagnosis was obtained by polymerase chain reaction amplification of bacterial deoxyribonucleic acid in brain abscess drain. Fusobacterium spp., should be considered in patients with any organ abscess, especially in case of invasive disease with multiple secondary site involving brain. techniques might be of special usefulness in cases that remain negative in culture to obtain the diagnosis and perform adequate treatment.

References

Oct 3, 2000·British Journal of Neurosurgery·R ChaudhryV S Mehta
Jul 24, 2003·Scandinavian Journal of Infectious Diseases·Gwenaël Le MoalBertrand Becq-Giraudon
Sep 23, 2008·The Journal of Infection·Paul J Huggan, David R Murdoch
May 29, 2012·The Lancet Infectious Diseases·Krutika KuppalliMelissa Osborn

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Citations

Nov 21, 2019·Nanoscale·Dan LiVincent Rotello
Jul 20, 2021·Curēus·Anuj KunadiaAneta Tarasiuk-Rusek

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Methods Mentioned

BETA
biopsy
nucleic acid amplification
PCR

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Brain Abscess

Brain abscess is an accumulation of pus caused by inflammation and infected materials in the brain. Symptoms include fever, headache, seizures and other neurological problems. Discover the latest research on brain abscess today.