PMID: 550751Oct 1, 1979

Detection of HBsAg and the related antibody (HBsAb) with the radioimmunological method. Behavior of the HBeAg-HBcAb system in HBsAg-positive patients

Archivio per le scienze mediche
L OrtonaG Camilli

Abstract

A radioimmunological assay was made of HBsAg and HBsAb in 183 patients during the course of acute viral hepatitis, 23 with prior HBsAg-positive hepatitis, 72 with chronic liver disease, 822 blood donors, 44 patients and 28 staff members from two dialysis centres, and the medical and paramedical staff of several high-risk departments. Microimmunodiffusion on agar was also used to determine HBeAg and HBeAb in the same 183 acute hepatitis patients, 37 HBsAg+ blood donors, 20 asymptomatic HBsAg carriers, the patients of two haemodialysis centres and the staff of departments at high risk for hepatitis B. Attention is drawn to the marked incidence (5.5%) of chronic HBsAg carriers in the blood donors, and the considerable circulation of virus B in the population examined, HBsAb-positivity (27.6%) being also an expression of this. Stress is also laid on the diagnostic and prognostic significance of the study of the HBsAg-HBsAb system during acute and chronic hepatitis. The importance of serum hepatitis B markers in the transmission of this disease in dialysis centres and other high-risk departments and in its prevention is underscored. Lastly, emphasis is laid on the appreciable progress that analysis of the e-anti-e system offers in t...Continue Reading

Related Concepts

Antibodies, Viral
Blood Donor
Carrier of Disorder
Hemodialysis
Hepatitis B
Hepatitis B Antibodies
Hepatitis B Antigens
Hepatitis B Surface Antigens
Personnel, Hospital
Radioimmunoassay

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