PMID: 7536119May 1, 1995Paper

Detection of Helicobacter pylori infection in early stage gastric cancer. A comparison between intestinal- and diffuse-type gastric adenocarcinomas

Cancer
S EndoC Sato

Abstract

Helicobacter pylori (H pylori) infection has been suggested to be a risk factor for gastric carcinogenesis. However, those previous studies have been concerned with advanced cancer cases. To the authors' knowledge, no detailed investigation on the prevalence of H pylori in early stage gastric cancer tissue has been performed. The relationship between early stage gastric cancer and the prevalence of H pylori was studied by a immunohistochemical staining analysis. Sixty-eight patients who were endoscopically and surgically diagnosed as having early stage gastric cancer were enrolled in this study. All tissue specimens were obtained from patients by endoscopic biopsy, and were classified histopathologically as the intestinal-type of early stage gastric cancer in 34 patients (male-to-female ratio, 28:6; age, 64 +/- 11 years) and the diffuse-type of early stage gastric cancer (male-to-female ratio, 23:11; age, 57 +/- 14 years) in the other 34 patients. The amount of H pylori in tissue samples was graded from 0 (no characteristic bacteria) to 3 (numerous bacteria) using the fluorescent microscopic and an immunohistochemical technique. Twenty-nine of the 34 cases of the intestinal-type of gastric cancer had H pylori infection, as comp...Continue Reading

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Citations

Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·T ShibataE C Gabazza
Feb 24, 2001·Journal of Gastroenterology and Hepatology·M KurosawaF Kobayashi
Oct 18, 2000·Journal of Clinical Gastroenterology·Y TokunagaK Ohsumi
Mar 19, 2003·Journal of Clinical Gastroenterology·Kunio TakeuchiHiroyuki Kuwano
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Aug 28, 1998·Gastroenterology·T WatanabeM Nakao
Jun 19, 2002·Arquivos De Gastroenterologia·L P PereiraH P Soares
May 25, 2007·The American Journal of Gastroenterology·Changcheng WangRichard H Hunt
Aug 10, 2013·European Journal of Gastroenterology & Hepatology·Joana I MatosMário Dinis-Ribeiro

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