PMID: 11327120May 1, 2001Paper

Detection of Helicobacter pylori infection: when to perform which test?

Annals of Medicine
B Braden, W F Caspary

Abstract

This paper reviews current diagnostic techniques for Helicobacter pylori infection and critically questions their value under different diagnostic circumstances. As long as we do not have general treatment recommendations for H. pylori infection, endoscopy is still the basis for primary diagnosis because it assesses therapy indications. In addition, histology characterizes the gastroduodenal lesions observed and may reveal malignant diseases. New rapid urease tests from the biopsies are inexpensive, simple, and quick giving results reliably within 1 h. Culturing H. pylori from gastric samples after therapy failure and testing the strains for antimicrobial susceptibility is becoming increasingly important with higher prevalence of drug resistances. Nonendoscopic tests are more convenient to the patient. Serological tests inexpensively detect circulating IgG or IgA antibodies. However, inspite of the cost attractiveness, serology might be problematic in indicating present H. pylori infection. The tests of choice for noninvasive monitoring therapy success or failure are the 13C-urea breath test and the faecal antigen immunoassay. Both tests are also of value for first diagnosis in children when endoscopy is not indicated. In the f...Continue Reading

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Citations

Oct 22, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·T H LeeT H Wang
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Douglas J PassaroJulie Parsonnet
Jun 3, 2009·Journal of Gastroenterology and Hepatology·Emel OztürkKemal Dağalp
Mar 29, 2012·Digestive Diseases and Sciences·Benito VelayosJosé M González-Hernández
Aug 5, 2006·Translational Research : the Journal of Laboratory and Clinical Medicine·Antone R OpekunKyoko Tsuchiya
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Nov 30, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Sandra Iveth Mendoza-IbarraElvira Garza-González
Aug 20, 2005·Scandinavian Journal of Gastroenterology·Emine Meral InelmenGiuliano Enzi
Aug 18, 2009·Revista Da Sociedade Brasileira De Medicina Tropical·Vivian D'Annibale CartágenesTereza Cristina Corvelo

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