Detection of Helicobacter pylori virulence-associated genes

Expert Review of Molecular Diagnostics
L J van Doorn

Abstract

Helicobacter pylori is an important human pathogen and persistent colonization of the human gastric mucosa can cause severe gastrointestinal diseases. The bacterium should not be considered as a uniform organism, but as a population of closely related and yet genetically diverse bacteria. Several genes of H. pylori (such as vacA and cagA) have been identified as being virulence-associated and may have important clinical and epidemiological implications. Assessment of virulence-associated genes of H. pylori should be included in clinical and epidemiological studies as well as therapeutic trials, in order to stratify between patient groups, harboring H. pylori strains with particular virulence genotypes. Molecular determination of antibiotic resistance will be especially useful for treatment studies. Together with our increasing knowledge about the human genome, typing of H. pylori will facilitate the management of gastroenterological pathologies.

References

Jul 1, 1991·Reviews of Infectious Diseases·R D Leunk
Dec 6, 1995·Journal of the National Cancer Institute·E J KuipersM J Blaser
Jun 15, 1994·Annals of Internal Medicine·A NomuraM J Blaser
May 1, 1993·Infection·Y LermanY L Danon
Mar 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T U WestblomS J Czinn
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A CovacciN Figura
May 20, 1996·The American Journal of Medicine·H L Mobley
Apr 1, 1996·Molecular Microbiology·T L Cover
Aug 15, 1996·FEMS Microbiology Letters·Y J Debets-OssenkoppC M Vandenbroucke-Grauls
Nov 1, 1996·American Journal of Clinical Pathology·M J Blaser, J E Crabtree
Dec 1, 1996·Gastroenterology·L J Miller
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·S CensiniA Covacci
Jan 1, 1997·European Journal of Gastroenterology & Hepatology·C W Venables
Oct 23, 1997·Clinical Microbiology Reviews·B E DunnM J Blaser
Jan 14, 1998·Molecular Microbiology·M de BernardC Montecucco
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·M C MaidenB G Spratt
May 9, 1998·Infection and Immunity·A van der EndeJ Dankert
Jul 3, 1998·Gastroenterology·L J van DoornW Quint
Aug 13, 1998·Alimentary Pharmacology & Therapeutics·P CorreaJ L Realpe
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·S SuerbaumM Achtman
Mar 26, 1999·Gastroenterology·L J Van DoornW G Quint
Aug 17, 1999·Journal of Clinical Microbiology·J C AthertonM J Blaser

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Citations

Oct 22, 2005·Digestive Diseases and Sciences·Farideh SiavoshiHassan Ashktorab
Oct 2, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·N A P KomenP W de Graaf
Dec 17, 2008·Digestive Diseases and Sciences·Zivar SalehiBehnam Kamalidehghan
Aug 15, 2003·World Journal of Gastroenterology : WJG·Wen QiaoHui Xue
Mar 6, 2004·International Journal of Immunopathology and Pharmacology·G Di BonaventuraR Piccolomini

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