Detection of Hemodynamically Significant Coronary Artery Stenosis With CT Enhancement Ratio: A Validation Study in a Porcine Model

AJR. American Journal of Roentgenology
Jun ChenZhengwen Yang

Abstract

Although numerous techniques that are based on CT number analysis have been proposed, the assessment of hemodynamically significant coronary artery stenosis remains a great challenge. The purpose of this study is to validate use of the CT enhancement ratio in the detection of hemodynamically significant coronary artery stenosis in a porcine model. Experiments involving eight closed-chest swine were performed. A balloon catheter was placed into the left anterior descending coronary artery to simulate different degrees of luminal stenosis. The myocardial blood flow (MBF) ratio was measured using the colored microsphere technique. The fractional flow reserve was measured using an invasive pressure wire. CT scans were performed during the first-pass phase, while the pigs were undergoing adenosine stress tests. The CT enhancement ratio and the CT attenuation ratio were calculated using data from the CT images obtained. Results suggested that the CT enhancement ratio had a strong correlation (y = 0.07245 + 0.09963x; r(2) = 0.898; p < 0.001) with the MBF ratio measured using the microsphere technique, whereas only moderate correlation (y = -1.5508 + 2.2684x; r(2) = 0.498; p < 0.001) was noted between the CT attenuation ratio and the M...Continue Reading

References

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Feb 26, 2015·AJR. American Journal of Roentgenology·Akos Varga-SzemesU Joseph Schoepf

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