PMID: 2114511Jan 1, 1990Paper

Detection of hepatic malignancies using Mn-DPDP (manganese dipyridoxal diphosphate) hepatobiliary MRI contrast agent

Magnetic Resonance Imaging
S W YoungD L Rubin

Abstract

A new hepatobiliary contrast agent (Mn-DPDP) was used in the detection of liver metastases in six rabbits with seven hepatic V2 carcinomas. This contrast agent is derived from pyridoxyl-5-phosphate which is biomimetically designed to be secreted by the hepatocyte. After Mn-DPDP administration, a 105% increase in liver signal to noise was obtained using a 200/20 (TR/TE) pulsing sequence, and a 62% decrease in intensity was observed using a 1200/60 pulsing sequence. Liver V2 carcinoma contrast enhancement increased 427% using the 200/20 pulsing sequence and 176% using the 1200/60 pulsing sequence. Four of seven V2 carcinomas were not detectable prior to the administration of Mn-DPDP (50 mumol/kg). Two neoplasms were only detectable in retrospect (after Mn-DPDP) on the 1200/60 sequence. The smallest neoplasms detected in this study were 1-4 mm. Mn-DPDP appears to be a promising MRI contrast agent.

References

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Citations

Jan 1, 1991·Journal of Magnetic Resonance Imaging : JMRI·F B MurphyM E Bernardino
Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·O CleméntR C Brasch
Sep 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·A TanimotoD D Stark
Jan 1, 1995·Journal of Magnetic Resonance Imaging : JMRI·B D ColeyA R Burgan
Dec 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H J WeinmannH Gries
Dec 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J A Nelson, U Schmiedl
Oct 22, 2003·Journal of Hepatology·Sassia BeddaFrédéric Batteux
Aug 18, 2010·Biologics : Targets & Therapy·Peter Reimer, Rolf Vosshenrich
Jan 13, 2006·European Journal of Radiology·Masayuki KanematsuNoriyuki Moriyama
Dec 13, 2005·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Akihiro Tanimoto, Sachio Kuribayashi
Jan 1, 1997·Journal of Computer Assisted Tomography·J T Halavaara, A E Lamminen

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