PMID: 9525631Apr 3, 1998Paper

Detection of hepatitis G virus replication sites by using highly strand-specific Tth-based reverse transcriptase PCR

Journal of Virology
Tomasz LaskusJorge Rakela

Abstract

The replication sites of the recently discovered hepatitis G virus (HGV) remain unknown. Using highly strand-specific Tth-based reverse transcriptase PCR, we searched for the presence of viral RNA negative strand in multiple autopsy tissues from four patients with AIDS and in peripheral blood mononuclear cells from six other human immunodeficiency virus-positive patients. Negative-strand HGV RNA was detected in three of four bone marrow samples, in two of two spleen samples, and in one of four liver tissue samples. However, the specific cellular site of replication within the positive tissues was not determined. This study does not support HGV as a primary hepatotropic virus.

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Citations

Feb 11, 2005·Current Gastroenterology Reports·Sarah L George, Dino Varmaz
Nov 22, 2005·The Journal of General Virology·Constanze Yue, Elke Genersch
Apr 26, 2007·AIDS·Thomas M KaufmanJack T Stapleton
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Sep 19, 2018·Emerging Infectious Diseases·Iwona Bukowska-OśkoTomasz Laskus
May 18, 1999·Biochemical and Biophysical Research Communications·M RadkowskiT Laskus

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