Oct 1, 1977

Detection of HLA-D clusters and segregation studies using primed LD typing

Tissue Antigens
P S CrosierJ Dausset

Abstract

By testing a group of PLT cells over a panel of unrelated restimulating cells, the PLT's could be grouped into clusters according to their ability to discriminate antigen(s) in unrelated cells. The PLT clusters broadly correlated with the homozygous typing cell-defined HLA-D clusters represented on the panel. The PLTs grouped together clearly segregate with a particular HLA haplotype when tested in both unrelated families not possessing the sensitizing haplotype and in the family with the sensitizing haplotype. No influence of HLA SD antigens could be observed in PLT restimulation in the segregation studies.

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Mentioned in this Paper

Antigenic Specificity
HLA Antigens
Immunogenetics
Antigens
HLA Typing
SD Antigens
HLA-D Antigens

About this Paper

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