PMID: 18711960Aug 21, 2008Paper

Detection of HPV DNA in lymph nodes in early stages cervical cancers

Ceská gynekologie
Jiri SlamaDavid Cibula

Abstract

Review recent knowledge concerning significance of detection of DNA HPV in regional lymph nodes in cervical cancer patients. Literature review. Department of Obstetrics and Gyneacology, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague. Metastatic involvement of pelvic lymph nodes is the most important prognostic parameter in early stages cervical cancer. Still, almost 20% of patients with negative pelvic nodes experience recurrence. Detection of HPV DNA in lymph nodes might be a marker of occult metastatic involvement. However, published data are limited, mostly due to inconsistent methodology. Only 3 prospective studies evaluating HPV from fresh or frozen tissue were published till now, all other retrospective studies extracted HPV DNA from paraffin embedded samples. A few papers showed correlation between HPV DNA and metastatic involvement of pelvic lymph nodes. DNA HPV identification in histopatology-negative nodes was considered as a risk factor for recurrence. Presence of DNA HPV 18 in histopathology-negative pelvic nodes was described as a poor prognostic factor; however prognostic significance of individual genotype is still unclear. Detection of high risk HPV DNA in regional lymph nodes ...Continue Reading

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