Detection of human Betaherpesvirinae in saliva and urine from immunocompromised and immunocompetent subjects.

Journal of Clinical Microbiology
A Gautheret-DejeanH Agut

Abstract

Human cytomegalovirus (HCMV) is a well-known opportunistic agent that reactivates in human immunodeficiency virus (HIV)-seropositive subjects. Human herpesvirus 6 (HHV-6) and HHV-7 were discovered recently and, like HCMV, belong to the Betaherpesvirinae subfamily. We looked for the presence of HCMV, HHV-6, and HHV-7 by PCR with saliva and urine samples from 125 HIV-seropositive patients at different stages of HIV infection and with saliva and urine samples from 29 HIV-seronegative subjects. All three viruses were frequently detected in the saliva (overall rates of detection, 61, 43, and 63% for HCMV, HHV-6, and HHV-7, respectively) with no correlation with the stage of immune deficiency. In contrast, HCMV was detected in urine much more frequently than the two other herpesviruses (overall rates of detection, 37, 2, and 6.5% for HCMV, HHV-6, and HHV-7, respectively) and was associated with immune deficiency. This suggests that these three genetically related viruses differ from each other with regard to replication in the urinary tract.

References

Nov 27, 1975·The New England Journal of Medicine·M HoJ A Armstrong
Nov 11, 1992·Proceedings of the National Academy of Sciences of the United States of America·Z N BernemanR C Gallo
Jan 1, 1990·Journal of Virology·G L LawrenceB G Barrell
Mar 1, 1990·Transplantation·T OkunoK Tanaka
Apr 1, 1989·Current Eye Research·H B QaviR L Font
Aug 1, 1989·Journal of Clinical Microbiology·K HsiaS A Spector
Oct 1, 1989·Journal of Clinical Pathology·N D FrancisA J Pinching
Feb 1, 1995·Immunology Today·P Lusso, R C Gallo
Jul 1, 1993·Virus Research·J B BlackP E Pellett
Feb 1, 1993·Journal of Medical Virology·E LuchtA Heimdahl
Sep 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A GautheretH Agut
Sep 1, 1995·Journal of Medical Virology·F WilbornW Siegert

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Citations

Sep 11, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N Fidouh-HouhouC Leport
Apr 28, 2005·Periodontology 2000·Jørgen Slots
Sep 10, 2010·Journal of Medical Virology·Patricia BiganzoliJorge Pavan
Dec 8, 2010·Periodontology 2000·Jørgen Slots, Henrik Slots
Oct 18, 2013·Journal of Medical Virology·Yasuto YamamotoTetsushi Yoshikawa
Mar 1, 2005·Journal of Periodontal Research·Işil SaygunJørgen Slots
Nov 21, 2001·The Journal of General Virology·M FrantiH Agut
Jun 13, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David BoutolleauDidier Ingrand
Apr 1, 2014·Viruses·Jesse D Deere, Peter A Barry
Jan 5, 2006·ILAR Journal·Peter A BarryAlice F Tarantal
Jul 2, 2020·Oral Diseases·Tami YapLaura Scardamaglia
Feb 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Minal M AminChengbin Wang
Aug 30, 2018·International Journal of Hematology·Kazuhito SuzukiShingo Yano
Mar 10, 2001·Journal of Medical Virology·A GonelliD Di Luca
Jul 20, 2002·The Lancet Infectious Diseases·François-Xavier Mbopi-KéouStephen R Porter
Nov 28, 2002·Journal of Clinical Microbiology·Daniela HüssyMathias Ackermann
Jul 15, 1998·Seminars in Arthritis and Rheumatism·H P FischerI J Russell

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