Detection of human papillomavirus DNA and p53 gene mutations in human prostate cancer

The Prostate
H SuzukiJ Shimazaki

Abstract

The relationship between integration with human papillomavirus (HPV) and p53 gene mutations in tissues of prostate cancer were examined. Tissue samples analyzed were obtained by total prostatectomy (29 stage B cancer cases) and from autopsy (22 endocrine therapy-resistant metastatic disease cases). HPV DNA was detected in 8 of 51 (16%, 5 in stage B and 3 in autopsy cases) by polymerase chain reaction (PCR) using consensus primers on L1 region. Genotypes of HPV were entirely type 16. Structural abnormalities of p53 gene were detected in 7 of the 22 autopsy cases (32%) by PCR-single-strand conformation polymorphism analysis and direct sequencing. No p53 gene mutation was found in stage B cancer cases. Analysis of mutation spectra revealed clear differences between Japanese and Westerners. There was a significant difference in the mutation frequency between stage B and autopsy cases (p < 0.01, Fisher's exact test). One case showed both integration of HPV and p53 gene mutation in different cancer foci. However, the other cases revealed an inverse correlation between the presence of HPV DNA and p53 gene mutations. These data show that p53 genetic alteration is correlated with the progression of prostate cancer, in contrast to the in...Continue Reading

References

May 1, 1991·Japanese Journal of Cancer Research : Gann·H YoshikawaA Iwamoto
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M ScheffnerP M Howley
May 10, 1991·International Journal of Cancer. Journal International Du Cancer·L L Villa, R R Brentani
Apr 1, 1991·The Journal of Urology·P J McNicol, J G Dodd
Jul 5, 1991·Science·M HollsteinC C Harris
Jun 6, 1991·Nature·A J LevineC A Finlay
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jan 15, 1986·International Journal of Cancer. Journal International Du Cancer·D J McCanceR Doll
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M DürstH zur Hausen
Oct 20, 1993·Journal of the National Cancer Institute·N M NavoneC J Conti
Sep 15, 1994·International Journal of Cancer. Journal International Du Cancer·K UzawaK Sato
Aug 1, 1994·Japanese Journal of Cancer Research : Gann·H SuzukiJ Shimazaki
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·H SuzukiJ Shimazaki
Mar 1, 1994·International Journal of Cancer. Journal International Du Cancer·W N DinjensJ Trapman
Jul 1, 1993·The Journal of Urology·P J EffertE T Liu

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Citations

May 13, 2008·Medical Hypotheses·Ala-Eddin Al Moustafa
Jun 7, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sean K LauLawrence M Weiss
May 1, 1997·Journal of the American Academy of Dermatology·S Majewski, S Jablonska
Oct 1, 1995·Japanese Journal of Cancer Research : Gann·H SuzukiJ Shimazaki
Jan 21, 2000·The Journal of Pathology·S A Burchill, P J Selby
Jan 9, 2004·Epidemiology·Rosebud O RobertsSteven J Jacobsen
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaojun ZhaoJinxian Pu
Oct 23, 2004·Carcinogenesis·Ganesh S PalapattuWilliam G Nelson
Jul 29, 2010·Scandinavian Journal of Infectious Diseases·Arezoo AghakhaniAmitis Ramezani
Feb 27, 1999·Endocrine Reviews·E RuijterJ Schalken
Jun 15, 2019·Pathology Oncology Research : POR·Tipaya EkalaksanananChamsai Pientong
Feb 18, 1998·International Journal of Cancer. Journal International Du Cancer·J DillnerA Aromaa
Jul 4, 2002·Annals of the New York Academy of Sciences·Giuseppe CarrubaLuigi Castagnetta
Sep 1, 1997·The Prostate·D G Tang, A T Porter
Aug 10, 2017·Oncology Letters·Binbin YinZhihua Tao

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