PMID: 11319292Apr 25, 2001Paper

Detection of human papillomavirus DNA in primary and metastatic lesions of carcinoma of the cervix in women from Okinawa, Japan

American Journal of Clinical Oncology
Y NagaiK Kanazawa

Abstract

Of 351 patients with invasive cervical cancer treated at Ryukyu University Hospital, Okinawa, 293 who were tested for human papilloma virus (HPV) DNA of the primary cervical lesion before the initiation of treatment were considered for the study. The polymerase chain reaction (PCR) was performed using fresh specimens, immediately after sampling. In 250 of 293 patients (85.3%), HPV DNA was detected in cervical tumor by PCR using L1 consensus primer. The positive rate by histology was 89.9% in squamous cell carcinoma, 93.8% in adenosquamous carcinoma, and 51.4% in adenocarcinoma. The former two figures were significantly higher than the latter (p < 0.001 and p = 0.002). Concerning identification of HPV types, HPV 16 was most predominant in squamous cell carcinoma, whereas type 18 was relatively high in adenocarcinoma. However, the type distribution of HPV was different to some extent from those in other countries. During treatment, 489 nodal and other tissue samples were obtained from 113 of 250 HPV DNA-positive patients, and were submitted to an assay of HPV DNA. HPV DNA was amplified in all 55 metastatic samples and also in 12 of 434 nonmetastatic tissues (2.8%). HPV types specified in these samples were always identical with t...Continue Reading

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Citations

Jul 7, 2005·Pathology Oncology Research : POR·Eduardo CambruzziCláudio Osmar Pereira Alexandre
Dec 12, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jose Antonio PlazaGerard J Nuovo
Jan 16, 2009·The American Journal of Surgical Pathology·Wilko WeichertIver Petersen
May 25, 2013·World Journal of Surgical Oncology·Seung Won ByunJong Sup Park
Dec 24, 2015·International Journal of Clinical Oncology·Shinichi OkameTakayoshi Nogawa
Jun 22, 2012·International Journal of Dermatology·Sumiyuki MiiKensei Katsuoka
Dec 5, 2014·Respirology Case Reports·Eun-Jung KoHye-Cheol Jeong
Dec 14, 2004·American Journal of Obstetrics and Gynecology·Yutaka NagaiKoji Kanazawa
Apr 17, 2004·Archives of Pathology & Laboratory Medicine·Janice Matthews-GreerElba A Turbat-Herrera

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