PMID: 11934017Apr 6, 2002Paper

Detection of human papillomavirus DNA, serum p53, and p53 antibodies in patients with cervical cancer

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
R C SobtiNeena Capalash

Abstract

Human papillomavirus (HPV) was detected in 85% and 63.6% of patients with invasive cervical cancer and minor cervical abnormalities, respectively. HPV-16 was the dominant type in both groups of women. Because of the high oncogenic potential of HPV-16 and the greater chance of its persistence, a follow-up of cases with minor cervical abnormalities harboring HPV-16 is warranted in order to observe the progression of the lesion. As many as 61.5% of the cases with invasive cervical cancer were found to have higher levels of serum p53 protein than did healthy controls. None of the patients had antibodies against the overexpressed p53. This suggests that, even if mutated, the p53 protein may not be immunogenic in all cases. An inverse relationship between the presence of HPV and the alteration in p53 expression was observed in 71.43% of the cases. This could mean the loss of p53 function as a result of either HPV-E6-mediated degradation or mutation in the p53 gene.

Citations

Dec 5, 2009·International Journal of Cancer. Journal International Du Cancer·Bozena DobrzyckaMarek Kulikowski
Jun 17, 2009·The Journal of Obstetrics and Gynaecology Research·Archana RaoJonathan Carter
Aug 22, 2009·Journal of Medical Virology·Alice Che-Ha ChenAnnika Antonsson
Jan 26, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Yu-Chi WeiTang-Yuan Chu
Aug 13, 2013·PloS One·Sándor SpisákIstván Csabai
May 14, 2008·The Journal of General Virology·Sabine BrandtChristian Stanek
Jul 15, 2004·Annals of the New York Academy of Sciences·Bret TabackDave S B Hoon
Dec 31, 2016·PloS One·Chiara GrassoLorenzo Richiardi
Jun 28, 2013·Journal of Clinical Microbiology·Anna Gillio-TosUNKNOWN New Technologies for Cervical Cancer Screening Working Group
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Dec 2, 2011·Archives of Pathology & Laboratory Medicine·Yongjung ParkHyon-Suk Kim

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