Detection of human papillomavirus in branchial cleft cysts

Oncology Letters
Taro IkegamiMikio Suzuki

Abstract

High-risk human papillomavirus (HPV) DNA has been reported to be present in branchial cleft cysts, but further information is required to clarify the role of HPV infection in branchial cleft cysts. The presence of HPV, the viral load and the physical statuses in samples from six patients with branchial cleft cysts were investigated using the polymerase chain reaction (PCR), quantitative PCR, in situ hybridization (ISH) using HPV DNA probes and p16INK4a immunohistochemical analysis. High-risk type HPV-16 DNA was identified in four of the six branchial cleft cysts analyzed. Of the HPV-positive branchial cleft cysts, three exhibited mixed-type integration of HPV. HPV DNA was distributed among the basal-to-granular layers of the cystic wall in ISH analysis, and p16INK4a was weakly expressed in the nuclei and cytoplasm of the same layers in patients with integration. ISH revealed that one patient with episomal-type infection exhibited HPV DNA in the cyst wall and did not express p16INK4a. Two patients without evidence of HPV infection exhibited weak p16INK4a expression in the superficial cyst-lining cells of branchial cleft cysts. These results indicate that infection with high-risk HPV types may be common in branchial cleft cysts. ...Continue Reading

References

Jan 1, 1992·American Journal of Obstetrics and Gynecology·C J TsengC C Pao
Jun 1, 1991·The Annals of Otology, Rhinology, and Laryngology·E M SmithL Turek
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·S Jeon, P F Lambert
Jun 1, 1994·British Journal of Obstetrics and Gynaecology·F PakarianJ M Best
Feb 1, 1993·The Australian & New Zealand Journal of Obstetrics & Gynaecology·B D FredericksI H Frazer
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·S N KhleifP M Howley
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Mark van DuinChris J L M Meijer
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·S Syrjänen, M Puranen
Dec 14, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark F EvansKumarasen Cooper
Jan 31, 2003·British Journal of Cancer·G M CliffordS Franceschi
Mar 9, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·John Cason, Christine A Mant
Apr 18, 2006·Seminars in Pediatric Surgery·John H T Waldhausen
May 5, 2006·Journal of Clinical Microbiology·Hugo Arias-PulidoCosette M Wheeler
Nov 4, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Stephan KnippingMarc Bloching
Oct 31, 2008·Acta Obstetricia Et Gynecologica Scandinavica·Marja E SarkolaStina M Syrjänen
Nov 26, 2008·The Laryngoscope·Myung Gu KimSeung Geun Yeo
Jun 18, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Stina Syrjänen
Feb 18, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Zeyi DengMikio Suzuki
Aug 29, 2012·ANZ Journal of Surgery·David Veivers, James Dent
Jan 13, 2015·Virology·Davit BzhalavaJoakim Dillner

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
surgical resection
PCR
cesarean section

Software Mentioned

BLAST

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Kazuyoshi ShigeharaMikio Namiki
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
François CoutléeEduardo L Franco
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
L Q XingJ Y Si
© 2022 Meta ULC. All rights reserved