PMID: 9434330Jun 1, 1996Paper

Detection of human T lymphotropic virus type I proviral DNA in patients with diffuse panbronchiolitis

Respirology : Official Journal of the Asian Pacific Society of Respirology
T MatsuseH Orimo

Abstract

In Japan a number of reported cases of diffuse panbronchiolitis (DPB) have been associated with human T lymphotropic virus type I (HTLV-I) infection. In this study the hypothesis that HTLV-I proviral DNA may be prevalent in DPB was examined using polymerase chain reaction (PCR) for the region of env or the two-step PCR for the pX region of this virus. The presence of HTLV-I proviral DNA was studied in the peripheral blood mononuclear cells (PBMC) obtained from 10 patients with DPB. The presence of proviral DNA in PBMC in 12 patients with chronic obstructive pulmonary disease (COPD), eight patients with idiopathic interstitial pneumonia (IIP), four patients disease were also studied as relevant controls. The lung tissue obtained from 11 patients with DPB, 12 patients with diffuse aspiration bronchiolitis (DAB) at autopsy, and the surgical lung samples obtained from 12 patients with bronchogenic cancer were also studied. Peripheral blood mononuclear cells obtained from one DPB patient and one bronchogenic carcinoma patient were positive for the HTLV-I pX region. The presence of the pX region was also found in the lung tissue of three DPB patients (27.3%) and one DAB patient (8.3%). None of other subjects were positive for HTLV-I ...Continue Reading

References

Jul 1, 1992·The American Review of Respiratory Disease·T MatsuseJ C Hogg
Jun 1, 1989·The American Review of Respiratory Disease·G Semenzato, C Agostini
Feb 25, 1989·Lancet·K NishiokaM Osame
May 3, 1986·Lancet·M OsameM Tara
Nov 21, 1987·Lancet·M SugimotoS Kawasaki
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M ShawF Wong-Staal
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M YoshidaY Hinuma
Jan 22, 1994·Lancet·K Yamaguchi

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