PMID: 60286Aug 15, 1976Paper

Detection of human tumor-associated antigens by the leukocyte migration in agarose assay

International Journal of Cancer. Journal International Du Cancer
A W BoddieD L Morton

Abstract

Twenty-three of 36 (64%) lung cancer patients, 19 of 36 (54%) melanoma patients and 18 of 27 (66%) sarcoma patients tested in the leukocyte migration in agarose assay against soluble extracts of histologically similar tumors showed significant inhibition of leukocyte migration. Reactivity to extracts of dissimilar tumors was low. Sera of only 1/13 (7%) lung cancer patients, 2/19 (10%) melanoma patients and 7/21 (33%) sarcoma patients were inhibited by extracts of histologically dissimilar tumors. Only 7-9% of cancer patients reacted to paired extracts of normal tissue from the tumor donors. An average of 13% of sera from normal controls reacted to tumor extracts. Stage of disease and mode of therapy appeared to have little effect on overall reactivity in this assay, although the number of patients within the various categories was small for purposes of statistical analysis. The leukocyte migration in agarose assay shows a sensitivity and specificity to tumor-associated antigens comparable to that of the older capillary tube method in general use and may facilitate performance of migration inhibition. This assay may not be useful as a prognostic test due to the lack ofcorrelation with stage of disease and treatment modality. How...Continue Reading

References

May 25, 1975·International Journal of Cancer. Journal International Du Cancer·A W BoddieD L Morton
Dec 25, 1975·International Journal of Cancer. Journal International Du Cancer·A W BoddieD L Morton
Jan 21, 1972·Nature·P Alexander
Jul 15, 1972·International Journal of Cancer. Journal International Du Cancer·C O'TooleF Edsmyr
Sep 1, 1973·Journal of the National Cancer Institute·T Borsos, H J Rapp
Aug 1, 1974·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Kjaer
Jul 15, 1974·International Journal of Cancer. Journal International Du Cancer·A J CochranJ M Russell
Jun 11, 1971·Science·R A ReisfeldB D Kahan
Feb 1, 1967·Acta Medica Scandinavica·M Soborg, G Bendixen

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Citations

Oct 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P B IlesM J Langman
Jan 1, 1980·Journal of Surgical Oncology·R K GuptaD L Morton

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