Detection of Hyperexcitability by Functional Magnetic Resonance Imaging after Experimental Traumatic Brain Injury

Journal of Neurotrauma
Joanna K HuttunenOlli H J Gröhn

Abstract

Diagnosis of ongoing epileptogenesis and associated hyperexcitability after brain injury is a major challenge. Given that increased neuronal activity in the brain triggers a blood oxygenation level-dependent (BOLD) response in functional magnetic resonance imaging (fMRI), we hypothesized that fMRI could be used to identify the brain area(s) with hyperexcitability during post-injury epileptogenesis. We applied fMRI to detect onset and spread of BOLD activation after pentylenetetrazol (PTZ)-induced seizures (PTZ, 30 mg/kg, intraperitoneally) in 16 adult male rats at 2 months after lateral fluid percussion (FPI)-induced traumatic brain injury (TBI). In sham-operated controls, onset of the PTZ-induced BOLD response was bilateral and first appeared in the cortex. After TBI, 5 of 9 (56%) rats exhibited ipsilateral perilesional cortical BOLD activation, followed by activation of the contralateral cortex. In 4 of 9 (44%) rats, onset of BOLD response was bilateral. Interestingly, latency from the PTZ injection to onset of the BOLD response increased in the following order: sham-operated controls (ipsilateral 132 ± 57 sec, contralateral 132 ± 57 sec; p > 0.05) < TBI with bilateral BOLD onset (ipsilateral 176 ± 54 sec, contralateral 178 ±...Continue Reading

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Citations

Apr 30, 2019·Brain Injury : [BI]·Efthimios DardiotisGeorgios M Hadjigeorgiou
Nov 22, 2020·NMR in Biomedicine·Karthik CharyOlli Gröhn
Feb 18, 2021·Nature Reviews. Neurology·Michele SimonatoKaren S Wilcox
Apr 23, 2020·Epilepsy & Behavior : E&B·Asla PitkänenNoora Puhakka
Jul 3, 2021·International Journal of Molecular Sciences·Xavier Ekolle Ndode-EkaneAsla Pitkänen
Aug 14, 2021·Neuroscience and Biobehavioral Reviews·Esther PototskiyAlberto E Musto
Jun 5, 2019··Suwatchai KamolsantirojPiyawat Saengpetch

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BETA
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ImageJ
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Brain Injury & Trauma

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