Detection of immunologically significant factors for chronic fatigue syndrome using neural-network classifiers

Clinical and Diagnostic Laboratory Immunology
S J HansonBenjamin H Natelson

Abstract

Neural-network classifiers were used to detect immunological differences in groups of chronic fatigue syndrome (CFS) patients that heretofore had not shown significant differences from controls. In the past linear methods were unable to detect differences between CFS groups and non-CFS control groups in the nonveteran population. An examination of the cluster structure for 29 immunological factors revealed a complex, nonlinear decision surface. Multilayer neural networks showed an over 16% improvement in an n-fold resampling generalization test on unseen data. A sensitivity analysis of the network found differences between groups that are consistent with the hypothesis that CFS symptoms are a consequence of immune system dysregulation. Corresponding decreases in the CD19(+) B-cell compartment and the CD34(+) hematopoietic progenitor subpopulation were also detected by the neural network, consistent with the T-cell expansion. Of significant interest was the fact that, of all the cytokines evaluated, the only one to be in the final model was interleukin-4 (IL-4). Seeing an increase in IL-4 suggests a shift to a type 2 cytokine pattern. Such a shift has been hypothesized, but until now convincing evidence to support that hypothesi...Continue Reading

References

Jun 1, 1990·Journal of Clinical Microbiology·N G KlimasM A Fletcher
Jan 1, 1989·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·A W TeelkenJ P Lakke
Jun 1, 1994·PCR Methods and Applications·W C Gause, J Adamovicz
Dec 1, 1994·Scandinavian Journal of Immunology·U TirelliA Pinto
Jan 1, 1993·Journal of Clinical Immunology·S E StrausW Strober
Feb 1, 1996·The Journal of Infectious Diseases·C M SwaninkJ W van der Meer
Jan 1, 1997·The Journal of Infectious Diseases·A C MawleW C Reeves
Jan 5, 1999·Clinical and Diagnostic Laboratory Immunology·Q ZhangB H Natelson
May 5, 1999·Journal of Clinical Immunology·J J LaMancaB H Natelson
Jul 13, 1999·International Journal of Neural Systems·M Lehtokangas

❮ Previous
Next ❯

Citations

Jun 3, 2005·Neuropsychology Review·Leonard A JasonCaroline King
Apr 14, 2006·Current Opinion in Psychiatry·Hyong Jin ChoSimon Wessely
May 12, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark PeakmanMatthew Hotopf
May 3, 2012·Journal of Mental Health·Leonard A Jason, Molly M Brown
Jun 2, 2015·Health Psychology and Behavioral Medicine·Leonard A JasonSuzanne D Vernon
Jan 24, 2004·Clinical and Experimental Immunology·A SkoweraM Peakman
Sep 19, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·L D Devanur, J R Kerr
Jan 15, 2015·Journal of Prevention & Intervention in the Community·Meredyth EvansLeonard A Jason
Jan 1, 2015·Journal of Human Behavior in the Social Environment·Leonard A JasonJordan Reed
Sep 9, 2008·Biochemical and Biophysical Research Communications·Kristine MetzgerKenny De Meirleir
Sep 6, 2005·Virology Journal·Daniel C Edelman
Jan 31, 2006·The American Journal of Medicine·Daniel BlockmansHerman Bobbaers
Sep 13, 2013·Clinical and Vaccine Immunology : CVI·Toru NakamuraBenjamin H Natelson
Feb 16, 2008·Journal of Muscle Research and Cell Motility·Stefania FulleGiorgio Fanò
Feb 26, 2010·Clinical and Vaccine Immunology : CVI·Toru NakamuraBenjamin H Natelson
Jul 3, 2002·Clinical and Diagnostic Laboratory Immunology·Benjamin H NatelsonNicholas M Ponzio
Mar 19, 2013·Fatigue : Biomedicine, Health & Behavior·Leonard A JasonMadison Sunnquist
Feb 11, 2014·Fatigue : Biomedicine, Health & Behavior·Leonard A JasonValerie Simonis
Aug 17, 2018·Fatigue : Biomedicine, Health & Behavior·Melissa L MehalickDedra S Buchwald
Aug 5, 2018·The Journal of Pharmacology and Experimental Therapeutics·Erifili HatziagelakiTheoharis C Theoharides

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.