PMID: 12948815Sep 2, 2003Paper

Detection of in vivo genotoxicity of endogenously formed N-nitroso compounds and suppression by ascorbic acid, teas and fruit juices

Mutation Research
Koh-ichi OhsawaYu F Sasaki

Abstract

The genotoxicity of endogenously formed N-nitrosamines from secondary amines and sodium nitrite (NaNO(2)) was evaluated in multiple organs of mice, using comet assay. Groups of four male mice were orally given dimethylamine, proline, and morpholine simultaneously with NaNO(2). The stomach, colon, liver, kidney, urinary bladder, lung, brain, and bone marrow were sampled 3 and 24 h after these compounds had been ingested. Although secondary amines and the NaNO(2) tested did not yield DNA damage in any of the organs tested, DNA damage was observed mainly in the liver following simultaneous oral ingestion of these compounds. The administration within a 60 min interval also yielded hepatic DNA damage. It is considered that DNA damage induced in mouse organs with the coexistence of amines and nitrite in the acidic stomach is due to endogenously formed nitrosamines. Ascorbic acid reduced the liver DNA damage induced by morpholine and NaNO(2). Reductions in hepatic genotoxicity of endogenously formed N-nitrosomorpholine by tea polyphenols, such as catechins and theaflavins, and fresh apple, grape, and orange juices were more effective than was by ascorbic acid. In contrast with the antimutagenicity of ascorbic acid in the liver, ascorb...Continue Reading

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Citations

Aug 8, 2013·Nutrition and Cancer·Silvia Isabel Rech FrankeDaniel Prá
Aug 26, 2009·Nutrition Reviews·Jennifer R PearsonIan R Rowland
Jan 14, 2012·Mutation Research·Tomoyasu ToyoizumiKohji Yamakage
Oct 17, 2015·Food Chemistry·Filis MorinaSonja Veljović-Jovanović
May 11, 2006·Immunopharmacology and Immunotoxicology·Jakub JabłońskiJanina Moniuszko-Jakoniuk
Mar 4, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Masayoshi AbeDai Nakae
Aug 27, 2013·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Suresh K Abraham, Nidhi Khandelwal
Nov 19, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Young-Su YangKyuhong Lee
Nov 9, 2016·Critical Reviews in Oncology/hematology·Olfa Baroudi, Amel Benammar-Elgaaied
Mar 21, 2007·Human & Experimental Toxicology·G MittalGiridhar Soni
Sep 23, 2014·Asia-Pacific Journal of Public Health·Qingkun SongJun Ren
Oct 21, 2005·Human & Experimental Toxicology·Jakub JablońskiMagda Marcińczyk
Jan 17, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Pei CaoHai-Bin Xu
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Apr 30, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Qing-Kun SongChen-Xu Qu
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Feb 4, 2006·Bioorganic & Medicinal Chemistry Letters·Maria De LuciaMarco d'Ischia

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