Detection of Incident Anal High-Risk Human Papillomavirus DNA in Men Who Have Sex With Men: Incidence or Reactivation?

The Journal of Infectious Diseases
Denise E TwiskMaarten F Schim van der Loeff

Abstract

We aimed to assess whether sexual exposure may explain all incident anal human papillomavirus (HPV) detections among men who have sex with men (MSM). A longitudinal study among MSM was conducted between 2010 and 2013 with visits every 6 months and up to 24 months of follow-up. Risk-factor questionnaires, blood samples, and anal and penile self-swabs were collected at each visit. Self-swabs were used for detection and genotyping of HPV by the broad spectrum L1 based SPF10 PCR DNA/enzyme immunoassay LiPA25 system. Serum samples were tested for high-risk HPV (hrHPV) antibodies. Incident anal HPV detection rates among sexually non-, low, and highly exposed MSM were compared. Factors associated with incident anal hrHPV detection were assessed using multivariable Cox regression. Seven hundred fourteen men (median age, 40 years; 39% human immunodeficiency virus [HIV] infected) were included in the analysis. Incident anal detections of all hrHPV types were observed among both sexually nonexposed and exposed MSM. In multivariable analyses, being highly sexually exposed, being HIV infected, and having a penile HPV infection were positively associated with incident anal HPV detection; those reporting more sex partners had a nonsignificant...Continue Reading

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Citations

Sep 1, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elske MarraMaarten F Schim van der Loeff
May 8, 2019·Human Vaccines & Immunotherapeutics·Maarten F Schim van der LoeffArjan Hogewoning
Feb 20, 2021·The American Journal of Gastroenterology·Suneela VeguntaMargaret E Long
Mar 18, 2021·Sexually Transmitted Infections·Ian K J WongUNKNOWN SPANC study team

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