Detection of influenza A virus in aerosols of vaccinated and non-vaccinated pigs in a warm environment

PloS One
Victor NeiraM Torremorell

Abstract

The 2009 influenza pandemic, the variant H3N2v viruses in agricultural fairs and the zoonotic poultry H5N9 infections in China have highlighted the constant threat that influenza A viruses (IAV) present to people and animals. In this study we evaluated the effect of IAV vaccination on aerosol shedding in pigs housed in warm environmental conditions. Thirty-six, three-week old weaned pigs were obtained from an IAV negative herd and were randomly allocated to one of 4 groups: 1) a homologous vaccine group, 2) a heterologous multivalent vaccine group, 3) a heterologous monovalent group and, 4) a non-vaccinated group. After vaccination pigs were challenged with the triple reassortant A/Sw/IA/00239/04 H1N1 virus. Environmental temperature and relative humidity were recorded throughout the study. Nasal swabs, oral fluids and air samples were collected daily. All samples were tested by RRT-PCR and virus isolation was attempted on positive samples. Average temperature and relative humidity throughout the study were 27°C (80°F) and 53%, respectively. A significantly higher proportion of infected pigs was detected in the non-vaccinated than in the vaccinated group. Lower levels of nasal virus shedding were found in vaccinated groups comp...Continue Reading

References

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Citations

Jul 29, 2018·Transboundary and Emerging Diseases·Juan MenaVíctor Neira
Aug 20, 2020·Transboundary and Emerging Diseases·Gonzalo López-LorenzoGonzalo Fernández
Jan 21, 2021·Preventive Veterinary Medicine·Jorge Garrido-MantillaMontserrat Torremorell

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