Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Tadao HasegawaMichio Ohta

Abstract

Streptococcal toxic shock syndrome (STSS) is a re-emerging infectious disease in Japan and many other developed countries. Epidemiological studies have revealed that the M1 serotype of Streptococcus pyogenes is the most dominant causative isolate of STSS. Recent characterization of M1 isolates revealed that the mutation of covS, one of the two-component regulatory systems, plays an important role in STSS by altering protein expression. We analyzed the M1 S. pyogenes clinical isolates before or after 1990 in Japan, using two-dimensional gel electrophoresis (2-DE) and pulsed-field gel electrophoresis (PFGE). PFGE profiles were different between the isolates before and after 1990. Markedly different profiles among isolates after 1990 from STSS and pharyngitis patients were detected. Sequence analysis of two-component regulatory systems showed that covS mutations were detected not only in STSS but also in three pharyngitis isolates, in which proteins from the culture supernatant displayed the invasive type. The mutated CovS detected in the pharyngitis isolates had impaired function on the production of streptococcal pyrogenic exotoxin B (SpeB) analyzed by 2-DE. These results suggest that several covS mutations that lead to the malf...Continue Reading

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Citations

Mar 19, 2011·Current Opinion in Infectious Diseases·Nicola N LynskeyShiranee Sriskandan
Mar 30, 2013·BMC Research Notes·Ichiro TatsunoTadao Hasegawa
Mar 5, 2011·Microbiology and Immunology·Masakado MatsumotoTadao Hasegawa
Oct 31, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ryo OkadaTadao Hasegawa
Dec 4, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Yan ZhangTadao Hasegawa
Apr 12, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Masanori IsakaTadao Hasegawa
Oct 4, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yasuko KamiyaYoshinori Ito
Oct 26, 2018·Frontiers in Microbiology·Catarina PatoUNKNOWN Portuguese Group for the Study of Streptococcal Infections
Jan 31, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tadao HasegawaIchiro Tatsuno
Sep 17, 2011·Nature Reviews. Microbiology·Jason N ColeMark J Walker
Aug 14, 2019·Microbiology and Immunology·Ichiro TatsunoTadao Hasegawa
Mar 29, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Songen ZhangHenrik Thorlacius

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