May 15, 1996

Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers

Cancer Letters
M A NelsonN C Clements


Oncogene and tumor suppressor gene mutations are candidate biomarkers for cancer risk assessment and lesion detection. The K-ras oncogene has previously been associated with non-small cell lung cancer (NSCLC), particularly adenocarcinomas in which reported rates of mutation have approached 30-40%. We have analyzed non-malignant lung tissue from patients with lung cancer and primary lung cancers for K-ras gene mutations. Mutations were detected in 32% cancers and 29% non-malignant lung tissue from patients with cancer. The majority of tumors testing positive were adenocarcinoma of the lung. Normal DNA controls, including peripheral blood lymphocytes and normal lung from non-smokers, were negative. The ability to detect genetic alterations in non-malignant lung tissues is consistent with the concept that genetic alterations are involved in field cancerization of the aerodigestive tract.

  • References18
  • Citations33


  • References18
  • Citations33


Mentioned in this Paper

Adenocarcinoma of Lung (Disorder)
TNM Staging System
Peripheral Blood
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Non-Small Cell Lung Cancer Pathway
Non-Small Cell Lung Carcinoma
v-Ki-ras Genes

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