Detection of Kaposi's sarcoma-associated herpesvirus-like DNA sequence in vascular lesions. A reliable diagnostic marker for Kaposi's sarcoma

American Journal of Clinical Pathology
Y T JinI J Su

Abstract

A new herpesvirus-like DNA sequence (KSHV) has been recently identified in Kaposi's sarcoma (KS) from patients with AIDS and non-AIDS patients. To verify the specificity of the association of this new viral DNA with KS, a total of 155 cases of benign and malignant vascular neoplasms sharing similar histogenesis of endothelial derivation were analyzed for the presence of this KSHV sequence using the published 330-233 primers by polymerase chain reaction (PCR). The results revealed that all 17 cases of KS, both AIDS and non-AIDS, were positive for this KSHV, whereas the remaining 138 cases of vascular lesions other than KS, including 15 cases of angiosarcoma, showed negative reaction. These results confirm and extend the previous observation that this KSHV sequence is specifically associated with KS and is a reliable diagnostic marker to distinguish KS, particularly at its early stage, from other vascular lesions.

Citations

Nov 24, 1998·Journal of Cutaneous Pathology·N LiJ Bhawan
Jun 13, 2001·Journal of Cutaneous Pathology·M Nuovo, G Nuovo
Jul 1, 1997·The American Journal of Surgical Pathology·D A ArberL M Weiss
Dec 16, 1998·Molecular Pathology : MP·S J NaylerK Cooper
Jan 22, 2002·The American Journal of Dermatopathology·A E AllanJ Bhawan
Jul 27, 2002·The American Journal of Dermatopathology·Iftikhar Ahmed, Kirsten L Hamacher
Jan 19, 2017·Anais Brasileiros De Dermatologia·João AvanciniCyro Festa
Dec 6, 2003·The American Journal of Surgical Pathology·Erich J SchwartzSabine Kohler
Mar 17, 2005·Journal of Cutaneous Pathology·James A RamirezJoan Guitart
May 2, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S Ramos-da-SilvaC E Bacchi
Sep 23, 1997·Seminars in Cutaneous Medicine and Surgery·M Dictor
Jan 31, 1998·The British Journal of Dermatology·R GyulaiA Dobozy
Aug 1, 1997·AIDS Patient Care and STDs·J L Helton
Jun 9, 2005·Critical Reviews in Clinical Laboratory Sciences·Adina CohenRonit Sarid
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C Boshoff, R A Weiss
Oct 30, 2008·Ultrastructural Pathology·Jan Marc Orenstein
Apr 24, 1999·The British Journal of Dermatology·I PalaciosA Celada
May 15, 1998·The British Journal of Dermatology·J A Martínez-EscribanoA Aliaga
May 27, 1999·Seminars in Cancer Biology·E Cesarman, D M Knowles
Jul 11, 1998·Oral Oncology·S R PorterN Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.