Abstract
The presence of cortical senile plaques and neurofibrillary tangles sufficient to warrant a neuropathological diagnosis of Alzheimer's disease is well established in middle-aged individuals with Trisomy 21 (Down's syndrome). In contrast a relationship between Down's syndrome and Lewy bodies, one of the major neuropathological features of Parkinson's disease, has not been previously reported. In a clinico-neuropathological survey of 23 cases of Down's Syndrome, two patients, aged 50 and 56 years respectively, were found to have Lewy body formation in the substantia nigra in addition to cortical Alzheimer-type pathology. Neither case showed significant substantia nigra neuron loss although locus coeruleus loss was present in both. Since substantia nigra Lewy bodies are a characteristic neurohistological feature of idiopathic Parkinson's disease, their occurrence in cases of Down's syndrome with evidence of Alzheimer-type pathology supports an aetiopathological connection between Parkinson's disease, Alzheimer's disease, and Down's syndrome; and suggests that common pathogenic mechanisms may underlie aspects of neuronal degeneration in these three disorders, some of which may relate to aberrant chromosome 21 expression.
References
Mar 30, 1992·Neuroscience Letters·P L LantosM Rossor
Jul 1, 1991·Neurobiology of Aging·M HaltiaB Frangione
Jan 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·P ViereggeB Schulze
Dec 1, 1991·Archives of General Psychiatry·J B Lohr
Oct 31, 1991·Nature·M C Chartier-HarlinJ Hardy
Dec 1, 1990·Journal of the Neurological Sciences·R H PerryB E Tomlinson
Jan 1, 1990·Neurology·L HansenM Klauber
Feb 1, 1990·Journal of the Neurological Sciences·R H PerryE K Perry
Jun 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·H GodridgeM Benton
Nov 1, 1988·Journal of Neuropathology and Experimental Neurology·P G GallowayG Perry
Feb 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·W R GibbA J Lees
Jun 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·W R GibbA J Lees
Jan 21, 1989·Lancet·R H PerryA F Fairbairn
Jun 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·W R Gibb, A J Lees
Mar 1, 1985·Annals of Neurology·K E WisniewskiG Y Wen
Jul 1, 1985·Neurology·K E WisniewskiH M Wisniewski
Aug 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Citations
Mar 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·A DanieleB Partolomeo
Apr 5, 2001·International Journal of Geriatric Psychiatry·M Simard, R van Reekum
Mar 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·A HestnesA Brun
Nov 29, 2011·FEBS Letters·Federico Herrera, Tiago Fleming Outeiro
Mar 11, 1999·Annals of Neurology·C F LippaJ Q Trojanowski
Apr 18, 1998·Brain Pathology·P G InceC M Morris
Sep 12, 2014·Journal of Neurology·Satoshi YamashitaYukio Ando
Jul 12, 2020·Journal of Alzheimer's Disease : JAD·Kelly M BakulskiSung Kyun Park
May 7, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Richard A ArmstrongNigel J Cairns
Dec 3, 2014·Human Molecular Genetics·Gonçalo M PoçasPedro M Domingos
Apr 19, 2018·Case Reports in Neurological Medicine·Padmini PalatElise Sannar
Jun 1, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Vanessa CarvalhoLeonor Correia Guedes
Jul 21, 2004·Lancet Neurology·C Warren OlanowKevin St P McNaught
Oct 30, 2021·Brain Pathology·Marina FriesenMelanie Meyer-Luehmann