Detection of lipoatrophy in human immunodeficiency virus-1-infected children treated with highly active antiretroviral therapy

The Pediatric Infectious Disease Journal
Karin HartmanNico G Hartwig

Abstract

Highly active antiretroviral therapy has been associated with lipodystrophy in adults. Much is unknown about its characteristics, especially in children. To obtain an objective case definition of the lipodystrophy syndrome. This was a cross-sectional study. One investigator rated clinical lipodystrophy. Body composition was measured using body mass index, skin fold thickness and circumference of arm, leg, waist and hip. Samples for human immunodeficiency virus (HIV)-1 RNA, CD4 cell count, fasting lipids and glucose variables were drawn. HIV-infected children with lipodystrophy were compared with HIV-infected children without lipodystrophy (controls). Thirty-four children were included: 28 controls, 2 nonassigned, and 4 with the lipoatrophic phenotype. Lipohypertrophy or mixed syndrome were not observed. All children with lipoatrophy were pubertal; they had used stavudine and didanosine longer. Children with lipoatrophy had significantly smaller arm and leg circumference, and their skin folds were thinner. The torso-to-arm ratio was 3 times higher in lipoatrophic children, but the difference did not reach significance. The waist-to-hip ratio was higher (P = 0.005). None of the laboratory values differed significantly between the...Continue Reading

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Nov 13, 2009·Indian Journal of Pediatrics·Ankit ParakhAnshu Maheshwari
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Apr 9, 2010·The Pediatric Infectious Disease Journal·Salvador ResinoUNKNOWN Spanish Group of Pediatric HIV Infection
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