PMID: 7014348Jan 1, 1981Paper

Detection of liver IgG Fc receptors using soluble immune complexes of peroxidase-antiperoxidase. II. Detection in liver tissue from mice with D-galactosamine-induced hepatitis

Gastroenterologia Japonica
T Shinohara

Abstract

The presence of liver IgG Fc receptor sites was demonstrated in the liver tissue from C-57 black mice with D-Galactosamine (GalN)-induced hepatitis by the localization of soluble immune complexes of peroxidase-antiperoxidase (PAP). Cryostat sections of liver tissues were incubated with the complexes and the peroxidase activity was revealed histochemically. In the normal liver tissue, PAP were localized on the Kupffer cells, some of the sinusoidal walls, and the liver cell membrane mainly at the side of the sinusoid. Twenty-four hours after single administration of GalN (1,500 mg/kg body weight), positive PAP reaction was mainly observed on the membrane surface of infiltrating cells in the area of hepatocellular focal necrosis, and faintly observed on the degenerative hepatic cell membrane and the sinusoidal walls. After 48 hours, these features became more remarkable, especially at the sites with severe necrotic lesions. After 72 hours, the positive reaction on the regenerative hepatic cell membranes again became distinct. At the chronic stage 13 weeks after repeated administrations of GalN and Freund's complete adjuvant, a strong positive reaction was found on swollen and multiplied Kupffer cells, and a faint one found on the ...Continue Reading

References

Jun 1, 1978·Clinical Immunology and Immunopathology·Y MizoguchiT Umeda
Mar 8, 1979·The New England Journal of Medicine·M M FrankP H Plotz
Oct 1, 1968·Experimental and Molecular Pathology·D KepplerK Decker
Aug 1, 1960·Archives of Biochemistry and Biophysics·A NISONOFFD L WOERNLEY

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.