Detection of localized retinal nerve fiber layer defects with posterior pole asymmetry analysis of spectral domain optical coherence tomography

Investigative Ophthalmology & Visual Science
Je Hyun SeoDong Myung Kim

Abstract

To investigate the diagnostic ability of posterior pole asymmetry analysis (PPAA) with spectral domain optical coherence tomography (SD-OCT) for detecting localized retinal nerve fiber layer defects (RNFLD). Eighty-four open-angle glaucoma subjects (84 eyes) with localized, wedge-shape RNFLDs by red-free RNFL photography and 122 eyes of healthy subjects were enrolled. The subjects were examined by SD-OCT to obtain circumpapillary RNFL (cpRNFL) thickness as well as PPAA. The PPAA provides a corresponding cell to cell comparison between hemispheres within the central 20° and presents the difference using gray scale. Area under the receiver operating characteristic curve (AUROC) was calculated. The sensitivity and specificity of PPAA to detect glaucoma with the localized defects were also examined using various criteria; two consecutive black cells (criterion A), three consecutive black cells (criterion B), and four consecutive black cells (criterion C). An AUROC of PPAA based on the number of black cells was 0.958 ± 0.013. The sensitivity and specificity of PPAA were 95.2% and 81.1% for criterion A, 83.3% and 92.6% for criterion B, and 69.0% and 98.4% for criterion C, respectively. The sensitivity and specificity of the cpRNFL th...Continue Reading

Citations

Jan 1, 2015·Expert Review of Ophthalmology·Tigran KostanyanJoel S Schuman
Dec 3, 2014·The Kaohsiung Journal of Medical Sciences·Gökhan PekelNihat Sayin
Aug 1, 2015·The Kaohsiung Journal of Medical Sciences·Gökhan PekelEbru Nevin Çetin
May 6, 2015·Clinical & Experimental Ophthalmology·Young Hoon HwangSung Ju Ko
Sep 10, 2014·American Journal of Ophthalmology·Hiroshi YamadaNagahisa Yoshimura
Apr 15, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Muhammed S AlluwimiVictor E Malinovsky
Jan 26, 2018·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Muhammed S AlluwimiBrett J King
Nov 1, 2012·Asia-Pacific Journal of Ophthalmology·Charles Kim, Nathan M Radcliffe
Jan 10, 2019·BMC Ophthalmology·Mei-Ju ChenCatherine Jui-Ling Liu
Aug 22, 2020·Translational Vision Science & Technology·Daisuke TakemotoKazuhisa Sugiyama
Feb 13, 2021·Journal of Ophthalmology·Pei-Wen LinYi-Chieh Poon
Apr 27, 2021·Journal of Glaucoma·Nevin W El-NimriRobert N Weinreb
Apr 18, 2020·Journal of the Neurological Sciences·Yung Ju YooChae-Yong Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.