Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors.

British Journal of Cancer
G PengH Haick

Abstract

Tumour growth is accompanied by gene and/or protein changes that may lead to peroxidation of the cell membrane species and, hence, to the emission of volatile organic compounds (VOCs). In this study, we investigated the ability of a nanosensor array to discriminate between breath VOCs that characterise healthy states and the most widespread cancer states in the developed world: lung, breast, colorectal, and prostate cancers. Exhaled alveolar breath was collected from 177 volunteers aged 20-75 years (patients with lung, colon, breast, and prostate cancers and healthy controls). Breath from cancerous subjects was collected before any treatment. The healthy population was healthy according to subjective patient's data. The breath of volunteers was examined by a tailor-made array of cross-reactive nanosensors based on organically functionalised gold nanoparticles and gas chromatography linked to the mass spectrometry technique (GC-MS). The results showed that the nanosensor array could differentiate between 'healthy' and 'cancerous' breath, and, furthermore, between the breath of patients having different cancer types. Moreover, the nanosensor array could distinguish between the breath patterns of different cancers in the same stat...Continue Reading

References

Feb 18, 1972·Science·S J Singer, G L Nicolson
Aug 1, 1994·Free Radical Biology & Medicine·C M KneepkensC C Roy
Jul 20, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·M PhillipsR N Cataneo
Apr 2, 2003·Cell Biology Education·Bruce Alberts, UNKNOWN National Academies
May 20, 2003·The Breast Journal·Michael PhillipsCynthia Wong
Jan 27, 2004·Health Care for Women International·Mandana Vahabi
Mar 3, 2006·Respiratory Physiology & Neurobiology·Matthias LechnerJosef Rieder
May 5, 2006·Analytical and Bioanalytical Chemistry·Gangfeng Ouyang, Janusz Pawliszyn
Feb 20, 2007·Mini Reviews in Medicinal Chemistry·Anton AmannDavid Smith
Apr 10, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Leiliane Coelho A Amorim, Zenilda de L Cardeal
Jan 22, 2008·Chemical Reviews·Frank RöckUdo Weimar
Jan 23, 2008·The British Journal of Radiology·M J Bermejo-PérezA Llanos-Méndez
Feb 22, 2008·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 3, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter J Mazzone
Dec 17, 2008·Medical Physics·Andrew Karellas, Srinivasan Vedantham
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Avinash BajajVincent M Rotello
Jul 2, 2009·The European Respiratory Journal·I HorváthG Losonczy
Sep 22, 2009·The Journal of Economic Perspectives : a Journal of the American Economic Association·David M Cutler
Oct 1, 2009·BMC Cancer·Amel BajtarevicAnton Amann
Oct 8, 2009·Nature Nanotechnology·Gang PengHossam Haick
Jan 9, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wojciech FilipiakJakob Troppmair

❮ Previous
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Citations

May 10, 2013·Nanomedicine·Yoav Y Broza, Hossam Haick
Apr 2, 2014·Prostate Cancer and Prostatic Diseases·A D AsimakopoulosE Finazzi-Agrò
Aug 1, 2014·Bioanalysis·Ben de Lacy Costello, Norman Ratcliffe
Oct 25, 2014·Nanomedicine·Morad K NakhlehHossam Haick
Apr 12, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Daniel F Moyano, Vincent M Rotello
Sep 9, 2011·Chemical Reviews·Radislav A PotyrailoAndrew Burns
Oct 5, 2011·Analytical Chemistry·Michelle L KovarikNancy L Allbritton
Feb 22, 2012·Interactive Cardiovascular and Thoracic Surgery·Enole BoedekerThorsten Walles
Oct 31, 2012·International Journal of Molecular Sciences·Paul ZarogouldisKonstantinos Zarogoulidis
Dec 25, 2012·Respiratory Research·Kim D G van de KantEdward Dompeling
Dec 1, 2012·Archives of Pathology & Laboratory Medicine·James Jett
Feb 9, 2016·Diagnostics·Thalakkotur Lazar MathewBiji Pullithadathil
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Arnaldo D'AmicoUNKNOWN U-BIOPRED study
Nov 10, 2015·Analytical Chemistry·Collin J BrightVincent P Schnee
Mar 12, 2016·Journal of the American Chemical Society·Subinoy RanaVincent M Rotello
Jun 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Wang LiLin-Hong Deng
Apr 17, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Michel R A van HoorenKenneth W Kross
Oct 9, 2013·Cancer Biology & Therapy·Changsong WangEnyou Li
Sep 1, 2015·Journal of Biomarkers·Kamila Schmidt, Ian Podmore
Nov 12, 2014·Bioanalysis·Rafael A García-MuñozAdolfo Toledano
Jun 28, 2016·Sensors·Julian W Gardner, Timothy A Vincent
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qin-Si Wan, Kun-He Zhang
Oct 13, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·R M G E van de GoorK W Kross
Jan 28, 2014·Journal of Laboratory Automation·Andrew O Fung, Natalia Mykhaylova
Aug 26, 2015·Scientific Reports·Luca LavraCorrado Di Natale
Apr 10, 2014·Scientific Reports·Yoav Y BrozaHossam Haick
Mar 10, 2017·IEEE Transactions on Nanobioscience·Siavash Ghavami, Farshad Lahouti
Oct 23, 2015·The Laryngoscope·Hagit Shoffel-HavakukDoron Halperin
Jan 7, 2015·Chest·Marc Philippe van der ScheePeter Jan Sterk
Mar 13, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Inbar Nardi-AgmonNir Peled

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Methods Mentioned

BETA
imaging
biopsy
PCA

Software Mentioned

Automated Mass Spectral Deconvolution and Identification Syste...

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