PMID: 8965658Mar 1, 1996Paper

Detection of MAO-A and MAO-B mRNAs in monkey brainstem by cross-hybridization with human oligonucleotide probes

Brain Research. Molecular Brain Research
J M LuqueJ G Richards

Abstract

The distribution of mRNAs encoding the isoenzymes monoamine oxidase A and B (MAO-A and MAO-B) in monkey locus coeruleus and dorsal raphe nucleus was studied by in situ hybridization histochemistry using 35S-labelled oligodeoxynucleotide probes complementary to cloned human sequences. MAO-A mRNA was highly expressed in noradrenergic neurons of the locus coeruleus while MAO-B mRNA was abundantly and exclusively localized in serotoninergic neurons of the raphe. However, upon emulsion radioautography raphe neurons showed a level of MAO-A mRNA signal noticeably above the background. Our results indicate the utility of human MAO oligodeoxynucleotide probes to identify homologous species of transcripts in the brain of a non-human primate. They also suggest the coexistence of the isoenzymes in raphe neurons as well as the potential role of MAO-A in metabolizing serotonin in vivo.

References

Jan 1, 1992·Psychopharmacology·J G RichardsM Da Prada
Oct 1, 1990·Journal of Neurochemistry·J GrimsbyJ C Shih
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A W BachJ C Shih
Oct 11, 1985·Science·K N WestlundC W Abell
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P LevittX O Breakefield
Mar 1, 1982·Journal of Neurochemistry·C J Fowler, K F Tipton
Dec 25, 1995·The Journal of Comparative Neurology·J M LuqueJ G Richards

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Citations

Mar 5, 1999·Molecular Neurobiology·C L BetheaZ N Lu
Feb 26, 1999·Brain Research. Molecular Brain Research·J M Luque, M E Wintzer
Mar 22, 2002·Frontiers in Neuroendocrinology·Cynthia L BetheaJohn M Streicher
Mar 19, 2014·Frontiers in Behavioral Neuroscience·Sean C Godar, Marco Bortolato
Mar 14, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A C ChenR L Sah
Jun 30, 2018·Current Neuropharmacology·Olivia Tania Hernández-HernándezGraciela Jiménez-Rubio
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Michel BottlaenderHeric Valette

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