Detection of microbubble formation during radiofrequency ablation using phonocardiography

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Pavitra KotiniMark A Wood

Abstract

To detect and characterize the acoustic energy generated by microbubble (MB) formation in an isolated tissue preparation. MB formation during radiofrequency (RF) ablation indicates excessive tissue heating and may precede explosive 'pops'. Currently, MB formation can only be detected with echocardiography. We hypothesized that MB formation can be detected with high-sensitivity phonocardiography. In a saline bath, RF lesions were created in sections of porcine left ventricle, using a 4 mm tip irrigated catheter. MB formation was visualized with an echocardiography probe. In 20 preparations, RF energy was begun at 25 W and increased by 5 W every 20 s until a pop occurred. A high-sensitivity computerized phonocardiography transducer with frequency bandwidth of 2 kHz and system noise -90 dB (SonoMedica, Inc., Vienna, VA, USA) was coupled to the external glass wall of the bath. In 15 of 20 (75%) preparations, a characteristic acoustic signature corresponding to MB formation was noted before the pop. These signals were within the 600-2000 Hz range and had an intensity range of 10-40 dB. The earliest MB and acoustic signals occurred 51.3+/-51.5 s before the pop. The acoustic signals continued intermittently up to 10.3+/-12.9 s before ...Continue Reading

References

Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mark A WoodEvan D Ownby

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Citations

Sep 1, 2009·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·David E Francischelli
Jul 5, 2013·Medical Physics·Chiao-Yin WangPo-Hsiang Tsui
Dec 18, 2014·Journal of Cardiovascular Electrophysiology·William W B ChikAravinda Thiagalingam
Sep 17, 2008·Optics Express·Stavros G Demos, Shiva Sharareh
May 21, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Rui André ProvidênciaAntónio Manuel Leitao-Marques

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