Detection of microcalcifications by characteristic magnetic susceptibility effects using MR phase image cross-correlation analysis

Medical Physics
Richard A BahezaThomas E Yankeelov

Abstract

To develop and evaluate a new method for detecting calcium deposits using their characteristic magnetic susceptibility effects on magnetic resonance (MR) images at high fields and demonstrate its potential in practice for detecting breast microcalcifications. Characteristic dipole signatures of calcium deposits were detected in magnetic resonance phase images by computing the cross-correlation between the acquired data and a library of templates containing simulated phase patterns of spherical deposits. The influence of signal-to-noise ratio and various other MR parameters on the results were assessed using simulations and validated experimentally. The method was tested experimentally for detection of calcium fragments within gel phantoms and calcium-like inhomogeneities within chicken tissue at 7 T with optimized MR acquisition parameters. The method was also evaluated for detection of simulated microcalcifications, modeled from biopsy samples of malignant breast cancer, inserted in silico into breast magnetic resonance imaging (MRIs) of healthy subjects at 7 T. For both assessments of calcium fragments in phantoms and biopsy-based simulated microcalcifications in breast MRIs, receiver operator characteristic curve analyses we...Continue Reading

References

Mar 1, 1992·AJR. American Journal of Roentgenology·D B Kopans
Jul 3, 1996·JAMA : the Journal of the American Medical Association·K KerlikowskeV Ernster
Aug 1, 1997·Physics in Medicine and Biology·A R CowenD S Brettle
Jun 19, 1998·American Journal of Preventive Medicine·A I MushlinD E Shapiro
Dec 5, 2000·Annals of Internal Medicine·K KerlikowskeR Ballard-Barbash
Jan 5, 2002·The British Journal of Radiology·J Law, K Faulkner
Oct 17, 2002·Journal of the National Cancer Institute·Virginia L ErnsterBerta M Geller
Jul 30, 2004·The New England Journal of Medicine·Mieke KriegeUNKNOWN Magnetic Resonance Imaging Screening Study Group
Aug 31, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E Mark HaackeJürgen R Reichenbach
Oct 29, 2005·Journal of Magnetic Resonance·Roy E Hoffman
May 23, 2006·AJR. American Journal of Roentgenology·Massimo BazzocchiAlessandro Del Maschio
Jan 19, 2007·The New England Journal of Medicine·Norman F BoydMartin J Yaffe
Mar 30, 2007·CA: a Cancer Journal for Clinicians·Debbie SaslowUNKNOWN American Cancer Society Breast Cancer Advisory Group
Jun 15, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy C DegnimLynn C Hartmann
Dec 20, 2008·Journal of Magnetic Resonance Imaging : JMRI·Zhen WuE Mark Haacke
Jan 26, 2010·Medical Physics·Ali Fatemi-ArdekaniMichael D Noseworthy
Aug 26, 2010·Radiology·R Edward Hendrick
Nov 18, 2010·Radiology·Martin J Yaffe, James G Mainprize
Mar 25, 2011·NMR in Biomedicine·Dennis W J KlompPeter R Luijten
Jun 13, 2013·European Journal of Radiology·Brian A HargreavesBruce L Daniel
Feb 19, 2013·Journal of Magnetic Resonance·Felix W Wehrli

❮ Previous
Next ❯

Citations

Jun 30, 2018·Journal of the American Heart Association·Ying WangYaming Li
May 8, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Evangelos Tzolos, Marc R Dweck
Mar 7, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Blerim MujajDaniel Bos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Saurav Z K SajibEung Je Woo
© 2022 Meta ULC. All rights reserved