Detection of micrometastasis in axillary lymph nodes of breast carcinoma patients and its association with clinical outcome

Indian Journal of Pathology & Microbiology
Indu Ramachandran NairVijaykumar Dehannaparambil Kottarathil

Abstract

There is heterogeneity in the clinical behavior of breast carcinoma patients with node negativity. Studies have analyzed different factors influencing the outcome in such patients. It is suggested that the presence of nodal micrometastasis can act as a tool in predicting the aggressiveness of these tumors. The aim of this study is to assess the yield of micrometastasis/isolated tumor cell (ITC) by ultrastaging the morphologically negative axillary nodes and staining them with immunohistochemistry for epithelial membrane antigen. The association of such metastasis with the clinical outcome is determined. This was a retrospective analytical study. One hundred cases of node-negative breast carcinoma patients who underwent surgery along with axillary lymph node dissection were selected. The largest node from the axillary dissection was selected and subjected to ultrastaging and immunohistochemical staining (as sentinel node dissection was not a routine practice at that time), to look for occult metastasis in the form of micrometastasis or ITCs. Occurrence of events in the form of recurrence or death was noted. Association of the parameters was analyzed using Fisher's exact test. Among the 100 cases, 79 patients were followed up for...Continue Reading

References

Jan 25, 2006·The Breast Journal·D Maxwell Parkin, Leticia M G Fernández
Jun 3, 2011·Breast Care·Michael GnantChristoph Thomssen
Mar 16, 2013·The Lancet Oncology·Viviana GalimbertiUNKNOWN International Breast Cancer Study Group Trial 23-01 investigators

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Citations

Jul 14, 2018·Indian Journal of Pathology & Microbiology·Ranjan Agrawal

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