Detection of mitochondrial biomarkers in eutopic endometria of endometriosis using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

Fertility and Sterility
X DingWei Zheng

Abstract

To detect specific mitochondrial proteins in eutopic endometrial samples from women with and without endometriosis and to build diagnostic models. Eutopic endometrial samples from women with endometriosis (excluding adenomyosis) and women with benign indications as control were studied by using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry protein-chip technology. After finding the biomarkers, the diagnostic model was evaluated and validated by leave-one cross-validation. Collaborative investigation in an academic research environment. Twenty-four patients with endometriosis (excluding adenomyosis) and 29 patients with benign indications as control. Surgical excision of eutopic endometrial biopsy of patients with endometriosis and controls. Mitochondrial protein expression. Seventy-eight qualified mitochondrial protein peaks were detected, ten of them had a significant difference. Three combined potential biomarkers, with mass-to-charge ratios (m/z) of 15,334, 15,128, and 16,069, were found, and the diagnostic system distinguished endometriosis from control samples with a specificity of 86.2% and a sensitivity of 87.5%. We discovered potential mitochondrial biomarkers of eutopic endometrium in en...Continue Reading

References

Oct 12, 2001·Annals of the New York Academy of Sciences·K L Sharpe-Timms
Jun 21, 2005·Annals of the New York Academy of Sciences·Shu-Huei KaoChii-Reuy Tzeng
Jan 5, 2006·Critical Reviews in Clinical Laboratory Sciences·Jacob Kagan, Sudhir Srivastava
Sep 23, 2006·Journal of the Society for Gynecologic Investigation·Murat UlukusAydin Arici
Feb 10, 2007·Expert Review of Proteomics·Terence C W Poon
Mar 8, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Liang WangSu-Zhan Zhang
Jul 11, 2008·Cell·Chris MeisingerNikolaus Pfanner
Feb 7, 2009·Reproductive Sciences·Peter A W RogersKrina T Zondervan

❮ Previous
Next ❯

Citations

Jun 16, 2011·Human Reproduction Update·K E MayC M Becker
Jun 14, 2013·Current Opinion in Obstetrics & Gynecology·Richard O Burney
Mar 19, 2014·Human Reproduction Update·Sang Jun Han, Bert W O'Malley
Oct 22, 2013·Human Reproduction Update·Giuseppe BenagianoMarwan Habiba
Feb 19, 2013·Fertility and Sterility·Amelie FassbenderThomas D'Hooghe
May 13, 2011·Fertility and Sterility·Aldo CavalliniGiuseppe Loverro
Jul 31, 2013·Proteomics. Clinical Applications·A B SivaSisinthy Shivaji
Aug 5, 2015·BioMed Research International·Amelie FassbenderLinda Giudice
Apr 21, 2016·The Cochrane Database of Systematic Reviews·Devashana GuptaVicki Nisenblat
Jan 25, 2012·Obstetrics and Gynecology·Amelie FassbenderThomas D'Hooghe
Aug 8, 2014·Journal of Proteome Research·Anni P VehmasGarry L Corthals

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.