Detection of molecular signatures and pathways shared in inflammatory bowel disease and colorectal cancer: A bioinformatics and systems biology approach.

Genomics
Md Al-MustanjidMohammad Ali Moni

Abstract

Emerging evidence indicates IBD is a risk factor for the increasing incidence of colorectal cancer (CRC) development. We used a system biology approach to identify common molecular signatures and pathways that interact between IBD and CRC and the indispensable pathological mechanisms. First, we identified 177 common differentially expressed genes (DEGs) between IBD and CRC. Gene set enrichment, protein-protein, DEGs-transcription factors, DEGs-microRNAs, protein-drug interaction, gene-disease association, Gene Ontology, pathway enrichment analyses were conducted to these common genes. The inclusion of common DEGs with bimolecular networks disclosed hub proteins (LYN, PLCB1, NPSR1, WNT5A, CDC25B, CD44, RIPK2, ASAP1), transcription factors (SCD, SLC7A5, IKZF3, SLC16A1, SLC7A11) and miRNAs (mir-335-5p, mir-26b-5p, mir-124-3p, mir-16-5p, mir-192-5p, mir-548c-3p, mir-29b-3p, mir-155-5p, mir-21-5p, mir-15a-5p). Analysis of the interaction between protein and drug discovered ASAP1 interacts with cysteine sulfonic acid and double oxidized cysteine drug compounds. Gene-disease association analysis retrieved ASAP1 also associated with pulmonary and bladder neoplasm diseases.

References

Feb 14, 2002·Trends in Molecular Medicine·Jonathan M Rhodes, Barry J Campbell
Dec 24, 2005·RNA·Praveen SethupathyArtemis G Hatzigeorgiou
Nov 24, 2006·Virchows Archiv : an International Journal of Pathology·Magali SvrcekJean-François Fléjou
Jan 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jianming YingQian Tao
Nov 13, 2010·Nucleic Acids Research·Sheng-Da HsuHsien-Da Huang
Mar 6, 2012·Journal of Crohn's & Colitis·Archanioti ParaskeviMaria Gazouli
Apr 17, 2012·Human Immunology·Macarena GuiradoRafael Carretero
Oct 24, 2012·Journal of Biomedicine & Biotechnology·Tingming LiangChang Liu
Nov 30, 2012·Nucleic Acids Research·Tanya BarrettAlexandra Soboleva
Oct 18, 2013·Journal of Surgical Oncology·Jennifer E HrabeJames J Mezhir
Jun 12, 2014·Virchows Archiv : an International Journal of Pathology·V PulkkinenJ Arola
Jul 22, 2014·Journal of Clinical Bioinformatics·Mohammad Ali Moni, Pietro Liò
Sep 2, 2014·BMC Bioinformatics·Philippe BardouChristophe Klopp
Oct 26, 2014·BMC Bioinformatics·Mohammad Ali Moni, Pietro Liò
Jan 2, 2015·Therapeutic Advances in Gastroenterology·Christopher G Chapman, Joel Pekow
Jun 18, 2015·Inflammatory Bowel Diseases·Natalya BenderskaRegine Schneider-Stock
Jul 15, 2015·Frontiers in Cell and Developmental Biology·Mohammad Ali Moni, Pietro Liò
Jan 2, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·C Austin PickensJenifer I Fenton
May 5, 2016·Nucleic Acids Research·Maxim V KuleshovAvi Ma'ayan
May 10, 2016·Expert Review of Clinical Immunology·Byong Duk Ye, Dermot P B McGovern
May 18, 2016·International Journal of Molecular Sciences·Jianhua WanNonghua Lu
Dec 8, 2016·Nucleic Acids Research·Damian SzklarczykChristian von Mering
May 13, 2017·Cell Reports·Jesper Bertram BramsenClaus Lindbjerg Andersen
Jul 5, 2017·Genes, Chromosomes & Cancer·Martha L SlatteryRoger K Wolff
Nov 11, 2017·Nucleic Acids Research·David S WishartMichael Wilson

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