PMID: 8595130Nov 1, 1995Paper

Detection of monocyte chemotactic and activating factor (MCAF) and interleukin (IL)-6 in human seminal plasma and effect of leukospermia on these cytokine levels

American Journal of Reproductive Immunology : AJRI
K ShimoyaO Tanizawa

Abstract

To demonstrate whether monocyte chemotactic and activating factor (MCAF) and interleukin-6 (IL-6) are present in the seminal plasma, and whether these presence is modulated by leukospermia. Semen samples from 53 men were obtained by masturbation and examined for the presence of MCAF and IL-6 by enzyme immunoassay (EIA). Semen samples were obtained from 28 infertile men without leukospermia, 16 infertile men with leukospermia, and nine proven-fertile men. The correlation between the amount of MCAF in the seminal plasma with some spermiogram parameters and other cytokines such as IL-6 and IL-8 was statistically evaluated. Immunoreactive MCAF was detected in the seminal plasmas of all 53 subjects. The MCAF titer in the seminal plasma of patients with leukospermia (11.19 +/- 2.75 micrograms/l) was significantly higher than that in the seminal plasma of the patients without leukospermia (3.24 +/- 0.53 micrograms/l) and the fertile men (2.78 +/- 0.35 micrograms/l) (P < 0.001). The IL-6 titer in the seminal plasma of the patients with leukospermia (21.05 +/- 4.49 ng/l) was also significantly higher than that in the seminal plasma of the patients without leukospermia (8.77 +/- 1.92 ng/l) and the fertile men (6.94 +/- 1.27 ng/l) (P < 0....Continue Reading

References

Feb 1, 1992·The Journal of Immunology : Official Journal of the American Association of Immunologists·F ColottaA Mantovani
Oct 1, 1991·International Journal of Andrology·M GavellaT Marotti
Sep 1, 1991·American Journal of Reproductive Immunology : AJRI·L A ThompsonI D Cooke
Jun 1, 1990·The Journal of Experimental Medicine·C O ZachariaeK Matsushima
Dec 15, 1989·Biochemical and Biophysical Research Communications·N IdaM Kohase
Dec 1, 1986·British Journal of Urology·M I el-DemiryG D Chisholm
Jan 1, 1986·Fertility and Sterility·A NaessensS Lauwers
Jan 1, 1980·Andrologia·C E SwensonW M O'Leary

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Citations

Oct 1, 1996·American Journal of Reproductive Immunology : AJRI·T NobunagaF Saji
Nov 22, 2014·The Journal of Infectious Diseases·Joseph A PolitchDeborah J Anderson
Oct 9, 2009·American Journal of Reproductive Immunology : AJRI·Srividya SeshadriD I Lewis Jones
Mar 17, 2004·Fertility and Sterility·Kumiko TemmaYuji Murata
Jun 4, 2002·Human Reproduction·Tetsuya IsobeNagayasu Toyoda
Nov 22, 2002·American Journal of Reproductive Immunology : AJRI·Ioannis MatalliotakisEvgenios Koumantakis
Jul 12, 2018·American Journal of Reproductive Immunology : AJRI·Giuseppe GrandeAlfredo Pontecorvi
Mar 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Nadia GopichandranNicolas M Orsi
Feb 3, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Shawn KeoganFred C Krebs
Apr 2, 2021·Human Reproduction·M Bendayan, F Boitrelle
Dec 8, 2020·EClinicalMedicine·M Bendayan, F Boitrelle

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