PMID: 7542911Jun 1, 1995Paper

Detection of multiple gains and losses of genetic material in ten glioma cell lines by comparative genomic hybridization

Genes, Chromosomes & Cancer
G MohapatraB G Feuerstein

Abstract

A protocol for comparative genomic hybridization by use of nucleotides directly labeled with fluorochromes was used to map regions of deletion and amplification in ten glioma cell lines. The protocol greatly reduced experimental artifacts. We detected several genetic aberrations, including whole chromosome loss and gain, partial loss and gain, possible isochromosome, and higher level DNA amplification. The most frequent losses (in order of frequency) occurred on chromosomes 10, 18, 13, 11, 9, 14, 4, 6, 1, and X. The most common gain occurred on chromosome 7. Several sites of previously known and unknown amplifications were observed.

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Citations

Jan 1, 1995·Journal of Neuro-oncology·B G Feuerstein, G Mohapatra
Feb 1, 1996·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·L James, J Varley
Jan 22, 2002·Cancer Genetics and Cytogenetics·Ahter Dilsad ToramanTekinalp Gelen
May 30, 2002·Cancer Genetics and Cytogenetics·Lydia NakopoulouPanayiotis Davaris
Mar 21, 2003·Cancer Genetics and Cytogenetics·Maaike van DartelTheo J M Hulsebos
Jan 1, 1997·Cancer Genetics and Cytogenetics·N C Popescu, D B Zimonjic
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Jan 15, 1998·Cancer Genetics and Cytogenetics·E P NachevaA R Green
Dec 24, 1997·Cancer Genetics and Cytogenetics·A PatelB G Feuerstein
Dec 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jonathan J LiSara Antonia Li
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Sep 27, 2006·Journal of Neuro-oncology·Alessia CompostellaAlba A Brandes
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anjan MisraBurt G Feuerstein

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