PMID: 9181662Jan 1, 1997Paper

Detection of Mycobacterium avium complex in cerebrospinal fluid of a sarcoid patient by specific polymerase chain reaction assays

Scandinavian Journal of Infectious Diseases
F A El-ZaatariL Engstrand

Abstract

The etiology of sarcoidosis is unknown, but it has long been suspected to be mycobacterial. In the present study, we used 4 mycobacterial species-specific polymerase chain reaction assays on cerebrospinal fluid obtained from a patient with neurosarcoidosis. Positive hybridization was observed with both the Mycobacterium avium complex probe and the insertion element IS900-specific probe that has been found in M. paratuberculosis species. There was no hybridization with M. tuberculosis or M. avium woodpigeon strain-specific probes. This case report demonstrates that M. paratuberculosis or some closely related M. avium spp which perhaps also carry IS900, or contain closely related DNA sequences, are associated with at least some cases of sarcoidosis disease.

References

Jul 4, 1992·Lancet·D Y GrahamF A el-Zaatari
Jul 1, 1992·Gut·J D SandersonJ Hermon-Taylor
Jul 1, 1989·Molecular Microbiology·A J HanceB Gicquel
Feb 1, 1987·Gastroenterology·D Y GrahamH H Yoshimura
Mar 4, 1995·Lancet·I MitchellR Williams
Feb 27, 1993·BMJ : British Medical Journal·H M FidlerJ McFadden
Sep 1, 1996·Journal of Clinical Microbiology·F A el-ZaatariD Y Graham

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Citations

Feb 18, 2003·Journal of Internal Medicine·R M du BoisP Cullinan
Sep 28, 2012·Current Opinion in Ophthalmology·Kayabasi A UmurOnultan Oguzhan
Jun 11, 2011·American Journal of Respiratory Cell and Molecular Biology·Isaac BrownellStephen Prystowsky
Apr 24, 2014·Journal of Ophthalmology·Maria M ChoudharyCareen Y Lowder
Jul 5, 2001·Journal of Comparative Pathology·J M GwozdzB W Manktelow
Feb 24, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·V S GuditM C Winterton
Jun 27, 1998·Current Opinion in Neurology·P Diaz-Villoslada, J R Oksenberg

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