Detection of myocardial capillary orientation with intravascular iron-oxide nanoparticles in spin-echo MRI

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Alexandre VignaudHan Wen

Abstract

In mammalian hearts the capillaries are closely aligned with the muscle fibers. We report our observation of a main-field direction-dependent contrast in MR spin-echo (SE) images of the heart in the presence of Ferumoxtran-10, an intravascular iron-oxide nanoparticle contrast agent (CA). We describe a novel MRI method for mapping the preferential orientation of capillaries in the myocardial wall. The eigenvector corresponding to the minimum eigen value of the R2 relaxation rate tensor is consistent with the expected orientation of the capillary network. Preliminary results also demonstrate the feasibility of this method for in vivo application to rodent imaging.

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Citations

Aug 4, 2010·European Radiology·Jean-François DeuxAlain Rahmouni
Jul 25, 2008·Nature Clinical Practice. Cardiovascular Medicine·Jeff Duyn, Alan P Koretsky
Apr 8, 2010·Journal of Magnetic Resonance Imaging : JMRI·Dimitrios C KarampinosJohn G Georgiadis
Jan 26, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiangzhi ZhouRohan Dharmakumar
Apr 14, 2016·Magnetic Resonance Imaging·F T KurzC H Ziener
Jan 1, 2013·Journal of Magnetic Resonance·Jeff Duyn
Jul 8, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Russell Dibb, Chunlei Liu
Oct 30, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Osama M AbdullahEdward W Hsu
Aug 29, 2017·Human Brain Mapping·Pol KennelFranck Plouraboué

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