PMID: 6978114Feb 1, 1982Paper

Detection of myocardial injury after coronary artery bypass grafting using a hypothermic, cardioplegic technique

The Annals of Thoracic Surgery
H G McDanielW A Lell

Abstract

Fifty patients undergoing isolated coronary artery bypass grafting procedures using a clear, cold cardioplegic solution, topical hypothermia, and reduced systemic flow for intraoperative myocardial protection were evaluated for myocardial injury by serial plasma creatine kinase-MB isoenzyme (CK-MB) measurements and electrocardiograms. Forty-one (82%) of the patients had three-vessel disease. Preoperative left ventricular contractility determined angiographically was normal in 13 patients (26%), mildly abnormal in 26 (52%), and moderately or severely abnormal in 11 (22%). The number of arteries grafted ranged from 2 to 6 (mean, 3.5). The mean duration of aortic clamping was 38.6 +/- 1.6 minutes. There were no hospital deaths. Enzymatic and electrocardiographic (ECG) evidence of myocardial infarction occurred in 1 patient. Nonspecific ECG changes occurred in 16 patients (32%), and th electrocardiograms were unchanged in the remaining 33 patients (66%). In the 49 patients without ECG evidence of infarction, the mean peak plasma CK-MB value, which occurred 6 hours after the onset of cardiopulmonary bypass, was 7.9 +/- 0.8 IU/L (standard error of the mean) and the mean integrated area 158 +/- 19.5 IU/L X hours. There was no correlat...Continue Reading

References

Oct 1, 1979·The American Journal of Cardiology·H R BaurF L Gobel
Jul 19, 1979·The New England Journal of Medicine·J W KirklinE H Blackstone
Nov 1, 1975·Circulation·R RobertsB E Sobel
Oct 1, 1972·Circulation·B E SobelR D Yoder

❮ Previous
Next ❯

Citations

Feb 1, 1985·The Annals of Thoracic Surgery·J E CoddV L Willman
Oct 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·U Jain
Jan 1, 1984·Skeletal Radiology·H J GriffithsJ Kimmel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.