Detection of myocardial perfusion abnormalities during dobutamine and adenosine stress echocardiography with transient myocardial contrast imaging after minute quantities of intravenous perfluorocarbon-exposed sonicated dextrose albumin

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
T R PorterU Deligonul

Abstract

We have recently discovered that if ultrasound transmission is briefly suspended (triggered to just one frame per cardiac cycle) after very small doses of intravenous perfluorocarbon-exposed sonicated dextrose albumin, the myocardial contrast produced is significantly enhanced. The objective of this study was to test whether this technique (termed transient response imaging) could identify myocardial perfusion abnormalities during adenosine and dobutamine stress echocardiography. In 10 open-chest dogs with a significant (> 50%) coronary stenosis determined by quantitative angiography, intravenous perfluorocarbon-exposed sonicated dextrose albumin (0.005 to 0.01 ml/kg) was given at rest during peak dobutamine stress (20 to 30 micrograms/kg/min). Adenosine stress (100 to 140 micrograms/kg/min) was also given in seven of these dogs. The peak myocardial videointensity and spatial extent of contrast defect with transient response imaging (TRI) were compared with conventional 30 Hz frame rates, as well as wall thickening and coronary flow responses. In all 10 dogs there was visually evident myocardial contrast with TRI. In comparison, myocardial contrast was visually evident in only one of these dogs with conventional imaging. The pe...Continue Reading

References

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Citations

Jul 10, 2002·Journal of the American College of Cardiology·Jian-Ping BinSanjiv Kaul
Jun 1, 2000·Coronary Artery Disease·D N Rubin, J D Thomas
Aug 12, 2005·Current Opinion in Cardiology·Jeane M TsutsuiThomas R Porter
Dec 17, 2002·Heart·Thomas H Marwick
Dec 8, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Patricia ReantAnthony DeMaria
Sep 4, 2007·Cardiology Clinics·Victor Mor-Avi, Roberto M Lang
Jul 21, 2004·The American Journal of Cardiology·Sharon L Mulvagh
Oct 3, 2006·Clinical Cardiology·Roberto M Lang, Victor Mor-Avi

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