Detection of narrow angles and established angle closure in Chinese residents of Singapore: potential screening tests

American Journal of Ophthalmology
W P NolanP J Foster

Abstract

To assess the performance of peripheral and central anterior chamber depth (ACD) measurements, and autorefraction, in identifying Chinese people with occludable drainage angles or established primary angle closure. Population-based cross-sectional analysis. Subjects aged 40 years and older were drawn from a representative sample of Chinese Singaporean residents. Limbal chamber depth (LCD) was estimated and central ACD was measured using optical pachymetry and ultrasound. An autorefraction was taken for all subjects. Angle width and the presence of peripheral anterior synechiae were determined by gonioscopy. Receiver operating characteristic curves were generated to show the performance of these tests in detecting occludable angles. A total of 1090 subjects were examined. The prevalence of occludable angles was 6.5%. LCD measurement performed best in detecting occludable angles (area under the curve [AUC] 0.904, 95% confidence interval [CI] 0.870, 0.937). Optical pachymetry and ultrasound measurement of ACD performed less well (AUC 0.859 and 0.810, respectively), and autorefraction performed poorly in detecting occludable angles (AUC 0.632). LCD also gave the best performance in detecting primary angle closure (AUC 0.782, 95% CI...Continue Reading

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Citations

Oct 26, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kenji KashiwagiShigeo Tsukahara
May 19, 2007·The British Journal of Ophthalmology·R J CassonT Aung
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Jun 16, 2011·Journal of Glaucoma·Yaniv BarkanaDavid Zadok
Jan 3, 2019·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Roxanne AnnohAndrew J Tatham
May 20, 2018·The British Journal of Ophthalmology·Lanhua WangMingguang He
Aug 3, 2018·The British Journal of Ophthalmology·Ramanjit SihotaRavindra M Pandey
May 30, 2020·The Cochrane Database of Systematic Reviews·Anish JindalJohn G Lawrenson
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Dec 24, 2016·European Journal of Ophthalmology·José Ignacio Fernández-VigoJosé Ángel Fernández-Vigo

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