Detection of NDM-1, VIM-1, KPC, OXA-48, and OXA-162 carbapenemases by matrix-assisted laser desorption ionization-time of flight mass spectrometry.

Journal of Clinical Microbiology
Jaroslav HrabákTamara Bergerová

Abstract

Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is a potentially useful tool for the detection of antimicrobial resistance, especially that conferred by β-lactamases. Here we describe a modification of a previously reported MALDI-TOF MS meropenem hydrolysis assay. The modified method was validated on 108 carbapenemase-producing members of the Enterobacteriaceae, two NDM-1-producing Acinetobacter baumannii isolates, and 35 carbapenem-resistant enterobacteria producing no carbapenemase. The detection of carbapenemases by MALDI-TOF MS seems to be a powerful, quick, and cost-effective method for microbiological laboratories.

References

Jul 22, 2011·Journal of Clinical Microbiology·Jaroslav HrabákTamara Bergerová
Sep 21, 2011·Antimicrobial Agents and Chemotherapy·Anna BaraniakUNKNOWN KPC-PL Study Group
Feb 1, 2012·Antimicrobial Agents and Chemotherapy·Yvonne PfeiferLaurent Poirel
Apr 18, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P NordmannUNKNOWN European Network on Carbapenemases

❮ Previous
Next ❯

Citations

Nov 2, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A LupettiM Campa
Aug 24, 2013·The Lancet Infectious Diseases·L Silvia Munoz-PriceJohn P Quinn
Jul 3, 2013·The Journal of Antimicrobial Chemotherapy·Marina R PulidoMichael J McConnell
Mar 27, 2013·Antimicrobial Agents and Chemotherapy·Costas C PapagiannitsisHelena Zemlicková
Apr 12, 2013·Journal of Clinical Microbiology·Kathryn M DayJohn D Perry
Nov 16, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·J HrabákUNKNOWN Czech Participants of European Antimicrobial Resistance Surveillance Network
May 3, 2014·BioMed Research International·Laurent DortetPatrice Nordmann
Sep 12, 2013·Future Microbiology·Antonis MarkogiannakisGeorge L Daikos
Dec 18, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J S JungA Wieser
Jan 28, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J SatlinThomas J Walsh
May 23, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A J M LoonenA J C van den Brule
Mar 29, 2014·Expert Review of Anti-infective Therapy·Alice Y GuhAlexander J Kallen
Oct 17, 2015·Expert Review of Proteomics·Alex van BelkumWm Michael Dunne
Feb 4, 2016·Annals of Clinical Microbiology and Antimicrobials·B GhebremedhinP Ahmad-Nejad
Aug 13, 2013·Clinics in Laboratory Medicine·Tanis C Dingle, Susan M Butler-Wu
Aug 11, 2015·Proteomics. Clinical Applications·Kyle A FloydMaria Hadjifrangiskou
Dec 30, 2015·Current Infectious Disease Reports·Kathleen ChiotosPranita D Tamma
Jan 7, 2015·Enfermedades infecciosas y microbiología clínica·Gabriel Alberto March Rosselló, Miguel Ángel Bratos Pérez
Mar 10, 2016·Journal of Mass Spectrometry : JMS·Elodie DuriezEric Ezan
Feb 26, 2015·Pathology·Theo P SlootsJonathan R Iredell
Jun 17, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C VogneG Greub
Aug 8, 2015·Journal of Applied Microbiology·J Osei SekyereS Y Essack
Aug 11, 2015·Journal of Chemotherapy·Abed Zahedi BialvaeiMehdi Yousefi
Nov 30, 2013·Letters in Applied Microbiology·Y Hoyos-MallecotJ M Navarro-Marí
Oct 15, 2013·Proteomics. Clinical Applications·Markus KostrzewaSören Schubert
Sep 5, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C MirandeS Chatellier
Apr 12, 2016·Frontiers in Microbiology·Priyanka BajajJugsharan S Virdi
Oct 14, 2014·Journal of Microbiological Methods·Yeng Pooi WongKwai Lin Thong
May 13, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J HrabákC C Papagiannitsis
Apr 12, 2014·BioMed Research International·Anastasia PavelkovichPaul Naaber
Apr 5, 2016·Expert Review of Molecular Diagnostics·Yasufumi Matsumura, Johann D Pitout
Jun 25, 2013·Diagnostic Microbiology and Infectious Disease·G CuzonP Nordmann
Oct 5, 2013·Diagnostic Microbiology and Infectious Disease·Agnese LupoAndrea Endimiani
Oct 4, 2014·Clinical Microbiology Reviews·Blake W Buchan, Nathan A Ledeboer
Jul 31, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L DortetP Nordmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acinetobacter Infections

Acinetobacter infections have become common in hospitalized patients, especially in the intensive care unit setting and are difficult to treat due to their propensity to develop antimicrobial drug resistance. Discover the latest research on Acinetobacter Infections here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.