Detection of nodal metastatic disease in patients with non-small cell lung cancer: comparison of positron emission tomography (PET), contrast-enhanced computed tomography (CT), and combined PET-CT

Clinical Imaging
Elisa VenturaMukesh G Harisinghani

Abstract

Of 31 patients with lung cancer, 19 underwent PET-CT and 12 had CT followed by PET. Thoracic lymph nodes were sampled by mediastinoscopy or thoracotomy. Sensitivities, specificities, positive (PPV), and negative predictive values (NPV) were calculated based on histopathology. Ninety nodes (41 malignant) were identified. Sensitivity, specificity, PPV, and NPV were 94%, 73%, 66%, and 96% for PET-CT, respectively. In 12 patients who underwent PET and CT separately, these values were 90%, 31%, 64%, and 71% for PET and 81%, 50%, 69%, and 66% for CT, respectively.

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Citations

Dec 1, 2012·Archives of Pathology & Laboratory Medicine·Liang GaoStephen T C Wong
Apr 5, 2011·European Journal of Radiology·Valentina AmbrosiniStefano Fanti
Nov 14, 2014·The Cochrane Database of Systematic Reviews·Mia Schmidt-HansenMarta Roqué I Figuls
Mar 18, 2011·Journal of Computer Assisted Tomography·Ahmed Abdel Khalek Abdel RazekTaha Abdel Gawad
May 11, 2016·Journal of Pathology and Translational Medicine·Soomin AhnWoong-Yang Park

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