Detection of non-melanoma skin cancer by in vivo fluorescence imaging with fluorocoxib A

Neoplasia : an International Journal for Oncology Research
Hyejun RaChristopher H Contag

Abstract

Non-melanoma skin cancer (NMSC) is the most common form of cancer in the US and its incidence is increasing. The current standard of care is visual inspection by physicians and/or dermatologists, followed by skin biopsy and pathologic confirmation. We have investigated the use of in vivo fluorescence imaging using fluorocoxib A as a molecular probe for early detection and assessment of skin tumors in mouse models of NMSC. Fluorocoxib A targets the cyclooxygenase-2 (COX-2) enzyme that is preferentially expressed by inflamed and tumor tissue, and therefore has potential to be an effective broadly active molecular biomarker for cancer detection. We tested the sensitivity of fluorocoxib A in a BCC allograft SCID hairless mouse model using a wide-field fluorescence imaging system. Subcutaneous allografts comprised of 1000 BCC cells were detectable above background. These BCC allograft mice were imaged over time and a linear correlation (R(2) = 0.8) between tumor volume and fluorocoxib A signal levels was observed. We also tested fluorocoxib A in a genetically engineered spontaneous BCC mouse model (Ptch1(+/-) K14-Cre-ER2 p53(fl/fl)), where sequential imaging of the same animals over time demonstrated that early, microscopic lesions ...Continue Reading

References

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Citations

Feb 20, 2016·Chemico-biological Interactions·Yonghwang Ha, Hyun-Kyung Choi
Jun 8, 2015·The Cancer Journal·Stephan Rogalla, Christopher H Contag
Sep 3, 2016·ACS Chemical Biology·Md Jashim UddinLawrence J Marnett
Feb 24, 2018·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Kathryn R TringaleQuyen T Nguyen
Sep 25, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Frederike S Arnold-BrüningMartina C Meinke
Nov 30, 2019·BMC Cancer·Jennifer BournMaria Cekanova
Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xinli WangMing Hu
Mar 14, 2020·Photodiagnosis and Photodynamic Therapy·Kamil BochynekAleksandra Kawczyk-Krupka

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Methods Mentioned

BETA
fluorescence imaging
Fluorescence
transgenic
xenografts
biopsies

Software Mentioned

Maestro

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